Nakai M, Iadecola C, Reis D J
Am J Physiol. 1982 Aug;243(2):H226-35. doi: 10.1152/ajpheart.1982.243.2.H226.
The effects of electrical stimulation of the pressor area of the fastigial nucleus (FN) of cerebellum on regional cerebral blood flow (CBF) were examined in anesthetized, paralyzed rats. CBF was measured in tissue homogenates by the Kety principle using 14C-iodoantipyrine as an indicator during FN stimulation, during stimulation of the vermal cortex, or after placement of electrodes in FN (unstimulated controls). Blood gases and systemic arterial pressures were comparable in the three groups. FN stimulation elicited a widespread and significant (P less than 0.005) increase in CBF in 12 of 13 areas. Flow was maximally increased in cerebral cortex (up to 220% of control) but also rose in selected regions of telencephalon, diencephalon, mesencephalon, lower brain stem, and in white matter of the corpus callosum (172%). Flow was not increased in cerebellum. The increase in CBF persisted after transection of the spinal cord at C1 or cervical sympathectomy. In five rats, hypercarbia (PCO2 to 63 mmHg) increased CBF in all 13 regions but in a pattern differing from FN stimulation. Excitation of neurons originating in, projecting to, or passing through FN can elicit a potent and virtually global increase of CBF. The effect appears mediated by intrinsic pathways of the central nervous system.
在麻醉、麻痹的大鼠中，研究了电刺激小脑顶核（FN）的升压区对局部脑血流量（CBF）的影响。在FN刺激期间、蚓部皮质刺激期间或电极置于FN后（未刺激对照），使用14C-碘安替比林作为指示剂，根据凯蒂原理在组织匀浆中测量CBF。三组的血气和全身动脉压相当。FN刺激在13个区域中的12个区域引起CBF广泛且显著（P<0.005）增加。大脑皮质血流增加最大（高达对照的220%），但端脑、间脑、中脑、脑桥下部的选定区域以及胼胝体白质（172%）的血流也增加。小脑血流未增加。在C1水平横断脊髓或颈交感神经切除术后，CBF的增加持续存在。在5只大鼠中，高碳酸血症（PCO2升至63 mmHg）使所有13个区域的CBF增加，但模式与FN刺激不同。起源于、投射至或通过FN的神经元兴奋可引起CBF有力且几乎全身性增加。该效应似乎由中枢神经系统的内在通路介导。
