Martin B J, Weil J V, Sparks K E, McCullough R E, Grover R F
J Appl Physiol Respir Environ Exerc Physiol. 1978 Oct;45(4):557-64. doi: 10.1152/jappl.1978.45.4.557.
To determine the relationship of ventilatory responsiveness to hypoxia and hypercapnia to exercise hyperpnea, these responses and steady-state exercise ventilation (VE) were measured in 16 athletes during light (1/3 VO2 max) and heavy (2/3 VO2 max) exercise. Both the hypoxic and hypercapnic ventilatory responses correlated positively with VE per unit metabolic rate (VE/VCO2) at both exercise levels (P less than 0.05). The contribution of the hypoxic response to normoxic exercise VE was quantified by comparing VE in normoxia to VE during a brief (1 min) exposure to high O2 (PAO2 = 200 Torr). High O2 reduced normoxic exercise VE by a mean of 20% at either exercise intensity. Among individuals this reduction was directly dependent upon the intensity of the hypoxic response, and ranged from 7 to 42% of normoxic VE. After the variable reduction of normoxic VE by hyperoxia, all correlations of ventilatory response with exercise VE were lost except for the correlation of hypercapnic response with heavy exercise VE/VCO2. These findings indicate that the extent of VE in light or heavy exercise is modified by the strength of the hypoxic ventilatory response, and that the hypercapnic response independently correlates with VE during heavy exercise.
为了确定低氧和高碳酸血症通气反应与运动性通气过度之间的关系，对16名运动员在轻度（1/3最大摄氧量）和重度（2/3最大摄氧量）运动期间的这些反应以及稳态运动通气量（VE）进行了测量。在两个运动水平下，低氧和高碳酸血症通气反应均与每单位代谢率的VE（VE/VCO2）呈正相关（P<0.05）。通过比较常氧下的VE与短暂（1分钟）暴露于高氧（PAO2 = 200 Torr）期间的VE，对低氧反应对常氧运动VE的贡献进行了量化。在任一运动强度下，高氧使常氧运动VE平均降低20%。在个体中，这种降低直接取决于低氧反应的强度，范围为常氧VE的7%至42%。在高氧使常氧VE发生可变降低后，除高碳酸血症反应与重度运动VE/VCO2的相关性外，通气反应与运动VE的所有相关性均消失。这些发现表明，轻度或重度运动中VE的程度受低氧通气反应强度的影响，并且高碳酸血症反应在重度运动期间与VE独立相关。
