儿童皮肌炎中的C反应蛋白
C-reactive protein in childhood dermatomyositis.
作者信息
Haas R H, Dyck R F, Dubowitz V, Pepys M B
出版信息
Ann Rheum Dis. 1982 Oct;41(5):483-5. doi: 10.1136/ard.41.5.483.
Abstract
Serum levels of C-reactive protein (CRP) were determined in 9 patients with childhood dermatomyositis. Four children were seen during clinical relapse and all had serum CRP levels less than 1 mg/l. In addition direct immunofluorescent staining of muscle biopsies from 4 patients showed no evidence of CRP deposition in muscle tissue. Such patients appear to be able to produce CRP in response to acute infections, and it is suggested therefore that the pathological process in childhood dermatomyositis may not induce a significant CRP response.
摘要
对9例儿童皮肌炎患者测定了血清C反应蛋白（CRP）水平。4名儿童处于临床复发期，其血清CRP水平均低于1mg/L。此外，对4例患者的肌肉活检进行直接免疫荧光染色，结果显示肌肉组织中无CRP沉积迹象。这类患者似乎能够对急性感染产生CRP，因此提示儿童皮肌炎的病理过程可能不会引起显著的CRP反应。
相似文献
1
C-reactive protein in childhood dermatomyositis.儿童皮肌炎中的C反应蛋白
Ann Rheum Dis. 1982 Oct;41(5):483-5. doi: 10.1136/ard.41.5.483.
2
Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis.髓系相关蛋白诱导青少年皮肌炎中肌肉来源的炎症介质。
Arthritis Res Ther. 2013 Sep 23;15(5):R131. doi: 10.1186/ar4311.
3
[Levels of acute-phase-reactants in patient with dermatomysitis and its correlations with IL-6 and dermatomyositis disease activity].
Sichuan Da Xue Xue Bao Yi Xue Ban. 2013 Sep;44(5):814-7.
4
Correlation of serum neopterin concentrations with disease activity in juvenile dermatomyositis.青少年皮肌炎患者血清新蝶呤浓度与疾病活动度的相关性
Arch Dis Child. 1993 Aug;69(2):232-5. doi: 10.1136/adc.69.2.232.
5
Increased Soluble Cytoplasmic Bcl-2 Protein Serum Levels and Expression and Decreased Fas Expression in Lymphocytes and Monocytes in Juvenile Dermatomyositis.在青少年皮肌炎患者的淋巴细胞和单核细胞中，可溶性细胞质 Bcl-2 蛋白血清水平升高，同时 Fas 表达降低。
J Rheumatol. 2018 Nov;45(11):1577-1580. doi: 10.3899/jrheum.171248. Epub 2018 Aug 1.
6
Elevated serum levels of interleukin-1 receptor antagonist in polymyositis/dermatomyositis. A biologic marker of disease activity with a possible role in the lack of acute-phase protein response.多发性肌炎/皮肌炎患者血清白细胞介素-1受体拮抗剂水平升高。一种疾病活动的生物学标志物，可能与缺乏急性期蛋白反应有关。
Arthritis Rheum. 1994 Dec;37(12):1744-51. doi: 10.1002/art.1780371206.
7
Increased osteopontin in muscle and serum from patients with idiopathic inflammatory myopathies.特发性炎性肌病患者肌肉和血清中骨桥蛋白增加。
Clin Exp Rheumatol. 2015 May-Jun;33(3):399-404. Epub 2015 May 1.
8
Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis.特发性炎性肌病患者白细胞介素 21 和白细胞介素 21 受体的上调。
Chin Med J (Engl). 2017 Sep 5;130(17):2101-2106. doi: 10.4103/0366-6999.213419.
9
Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis.肌炎特异性抗体和抗 MDA5 抗体与多发性肌炎及皮肌炎的相关性
肌炎特异性抗体和抗 MDA5 抗体与多发性肌炎及皮肌炎的相关性
Neuropathol Appl Neurobiol. 2019 Jun;45(4):410-420. doi: 10.1111/nan.12498. Epub 2018 Jun 4.
10
Diagnostic significance of membrane attack complex and vitronectin in childhood dermatomyositis.
J Child Neurol. 2005 Jul;20(7):597-602. doi: 10.1177/08830738050200071201.
引用本文的文献
1
C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.C反应蛋白：病理生理学、诊断、检测结果假阳性及面向临床医生的新型诊断算法
Diseases. 2023 Sep 28;11(4):132. doi: 10.3390/diseases11040132.
2
Use of C-Reactive Protein and Ferritin Biomarkers in Daily Pediatric Practice.C 反应蛋白和铁蛋白生物标志物在儿科日常实践中的应用。
Pediatr Rev. 2020 Apr;41(4):172-183. doi: 10.1542/pir.2018-0101.
3
Systemic and Tissue Inflammation in Juvenile Dermatomyositis: From Pathogenesis to the Quest for Monitoring Tools.幼年特发性皮肌炎的系统性和组织炎症：从发病机制到探索监测工具。
Front Immunol. 2018 Dec 18;9:2951. doi: 10.3389/fimmu.2018.02951. eCollection 2018.
4
Laboratory evaluation of the inflammatory myopathies.炎性肌病的实验室评估
Clin Diagn Lab Immunol. 1995 Jan;2(1):1-9. doi: 10.1128/cdli.2.1.1-9.1995.
5
Serum C-reactive protein concentrations in patients with pulmonary sarcoidosis.肺结节病患者的血清C反应蛋白浓度
Thorax. 1987 May;42(5):332-5. doi: 10.1136/thx.42.5.332.
本文引用的文献
1
C-reactive protein in the chronic rheumatic diseases.慢性风湿性疾病中的C反应蛋白
Lancet. 1951 Nov 3;2(6688):807-11. doi: 10.1016/s0140-6736(51)91595-4.
2
C-reactive protein levels in systemic lupus erythematosus: a classification criterion?系统性红斑狼疮中的C反应蛋白水平：一种分类标准？
Arthritis Rheum. 1980 Jun;23(6):770-1. doi: 10.1002/art.1780230609.
3
C-reactive protein in the differential diagnosis between infection and disease reactivation in SLE.C反应蛋白在系统性红斑狼疮感染与疾病再激活的鉴别诊断中的作用
J Rheumatol. 1981 Mar-Apr;8(2):291-4.
4
C-reactive protein fifty years on.五十年后的C反应蛋白。
Lancet. 1981 Mar 21;1(8221):653-7. doi: 10.1016/s0140-6736(81)91565-8.
5
Measurements of muscle strength and performance in children with normal and diseased muscle.
Arch Dis Child. 1976 Dec;51(12):957-63. doi: 10.1136/adc.51.12.957.
6
C-reactive protein in systemic lupus erythematosus.系统性红斑狼疮中的C反应蛋白
Arthritis Rheum. 1977 Jun;20(5):1065-70. doi: 10.1002/art.1780200505.
7
Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes.类风湿关节炎：血清C反应蛋白及红细胞沉降率与放射学改变的关系
Br Med J. 1977 Jan 22;1(6055):195-7. doi: 10.1136/bmj.1.6055.195.
8
Comparative clinical study of protein SAP (amyloid P component) and C-reactive protein in serum.血清中蛋白质SAP（淀粉样蛋白P成分）与C反应蛋白的比较临床研究
Clin Exp Immunol. 1978 Apr;32(1):119-24.
9
Significance of serum C-reactive protein elevation in patients with systemic lupus erythematosus.系统性红斑狼疮患者血清C反应蛋白升高的意义
Arthritis Rheum. 1979 Jan;22(1):7-12. doi: 10.1002/art.1780220102.
Zotero 插件