急性结肠炎静脉治疗期间的血浆泼尼松龙水平。
Plasma prednisolone levels during intravenous therapy in acute colitis.
作者信息
Berghouse L M, Elliott P R, Lennard-Jones J E, English J, Marks V
出版信息
Gut. 1982 Nov;23(11):980-83. doi: 10.1136/gut.23.11.980.
Abstract
Maximum plasma levels in six acute colitics were about three times greater after an intravenous bolus of 20 mg prednisolone than the mean level achieved during infusion of the same dose (p<0.001) over eight hours; the level during infusion was about twice as great as the maximum recorded previously after a single 40 mg oral dose of prednisolone. These findings favour the use of intravenous administration in severe acute colitis. No difference was found between plasma levels of patients and six normal subjects after the intravenous bolus.
摘要
6名急性结肠炎患者静脉推注20毫克泼尼松龙后的最大血浆水平比在8小时内输注相同剂量时达到的平均水平高约3倍（p<0.001）；输注期间的水平约为先前单次口服40毫克泼尼松龙后记录的最高水平的两倍。这些发现支持在重度急性结肠炎中使用静脉给药。静脉推注后，患者与6名正常受试者的血浆水平未发现差异。
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