Douglas N J, White D P, Pickett C K, Weil J V, Zwillich C W
Thorax. 1982 Nov;37(11):840-4. doi: 10.1136/thx.37.11.840.
Respiratory volumes and timing have been measured in 19 healthy adults during wakefulness and sleep. Minute ventilation was significantly less (p less than 0.05) in all stages of sleep than when the subject was awake (7.66 +/- 0.34(SEM) 1/min), the level in rapid-eye-movement (REM) sleep (6.46 +/- 0.29 1/min) being significantly lower than in non-REM sleep (7.18 +/- 0.39 1/min). The breathing pattern during all stages of sleep was significantly more rapid and shallow than during wakefulness, tidal volume in REM sleep being reduced to 73% of the level during wakefulness. Mean inspiratory flow rate (VT/Ti), an index of inspiratory drive, was significantly lower in REM sleep than during wakefulness or non-REM sleep. Thus ventilation falls during sleep, the greatest reduction occurring during REM sleep, when there is a parallel reduction in inspiratory drive. Similar changes in ventilation may contribute to the REM-associated hypoxaemia observed in normal subjects and in patients with chronic obstructive pulmonary disease.
对19名健康成年人在清醒和睡眠状态下的呼吸容量和时间进行了测量。与清醒状态（7.66±0.34（标准误）升/分钟）相比，睡眠各阶段的分钟通气量均显著降低（p<0.05），快速眼动（REM）睡眠阶段的水平（6.46±0.29升/分钟）显著低于非快速眼动睡眠阶段（7.18±0.39升/分钟）。睡眠各阶段的呼吸模式均比清醒时显著更快且更浅，REM睡眠时的潮气量降至清醒时水平的73%。平均吸气流量（VT/Ti），即吸气驱动力指标，在REM睡眠时显著低于清醒或非REM睡眠时。因此，睡眠期间通气量下降，最大降幅出现在REM睡眠期间，此时吸气驱动力也相应降低。通气的类似变化可能导致正常受试者和慢性阻塞性肺疾病患者出现与REM相关的低氧血症。
