Beadle P C, Leach J F
Arch Dermatol Res. 1982;274(1-2):47-56. doi: 10.1007/BF00510357.
The estimates of a dose-response model for human skin cancer (non-melanotic) incidence have been compared with the observed records for the Bristol area over the period 1952--1972. In general the model appears to respond more slowly than the real population. The trend of the model expectations agrees qualitatively with the observed data and correlation of annual incidences, although negligible in the first decade, is very good in the second (corr. factor = 0.74). The results indicate that an increase of 1% in dose might eventually lead to an increase of between 2% in skin cancer incidence.
已将人类皮肤癌(非黑素瘤)发病率剂量反应模型的估计值与1952年至1972年期间布里斯托尔地区的观测记录进行了比较。总体而言,该模型的反应似乎比实际人群更为缓慢。模型预期趋势与观测数据在定性上一致,且年度发病率的相关性在第一个十年中虽可忽略不计,但在第二个十年中非常好(相关系数 = 0.74)。结果表明,剂量增加1%最终可能导致皮肤癌发病率增加2%。