Giordano M, Isturiz M A, Colombo L
J Immunopharmacol. 1982;4(4):315-28. doi: 10.3109/08923978209019451.
The effect of cyclophosphamide (CY) on antibody dependent cell-mediated cytotoxicity (ADCC) was evaluated. The results indicated that a single injection of CY markedly increased ADCC activity of murine splenic cells. This effect was dose dependent and was maximal on day 7 after the drug injection. The number of lymphoid cells in treated mice decreased to approximately 50%; however the percentages of EA rosettes were similar to those of control animals suggesting that the augmented cytotoxic activity was not due to a relative increase in Fc receptor bearing cells. CY treatment also enhanced delayed type hypersensitivity, but suppressed antibody production to sheep red blood cells. The possibility that CY eliminates a suppressor cell subpopulation that normally regulates ADCC levels is discussed.
评估了环磷酰胺（CY）对抗体依赖性细胞介导的细胞毒性（ADCC）的影响。结果表明，单次注射CY可显著提高小鼠脾细胞的ADCC活性。这种作用呈剂量依赖性，在注射药物后第7天达到最大。经治疗的小鼠中淋巴细胞数量减少至约50%；然而，EA花环的百分比与对照动物相似，这表明增强的细胞毒性活性并非由于携带Fc受体的细胞相对增加所致。CY治疗还增强了迟发型超敏反应，但抑制了对绵羊红细胞的抗体产生。文中讨论了CY消除正常调节ADCC水平的抑制性细胞亚群的可能性。
