多发性硬化症中的血清麻疹抗体。
Serum measles antibodies in multiple sclerosis.
作者信息
Cendrowski W, Polna I, Niedzielska K
出版信息
J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):57-60. doi: 10.1136/jnnp.36.1.57.
Serum haemagglutination inhibition/HI/antibody titres to measles virus were examined in 80 multiple sclerosis patients, their 20 sibs, in 990 healthy controls, and 25 control patients. The measles HI titres were significantly raised in the serum of multiple sclerosis patients compared with healthy controls. There was no statistical difference between the levels of HI antibody titres in multiple sclerosis patients and their sibs. The measles HI titres decreased significantly in older age groups of healthy controls, whereas an analogous drop was not found in the multiple sclerosis group. The levels of serum HI antibody titres did not correlate with the sex of patients with multiple sclerosis or the activity of the disease. In the CSF of six multiple sclerosis patients low titres of HI antibodies were detected, whereas none of eight control patients had measurable traces of measles antibodies in the CSF. The significance of these findings in the aetiology of multiple sclerosis is briefly discussed.
对80例多发性硬化症患者、他们的20名同胞、990名健康对照者以及25名对照患者检测了针对麻疹病毒的血清血凝抑制（HI）抗体滴度。与健康对照者相比，多发性硬化症患者血清中的麻疹HI滴度显著升高。多发性硬化症患者及其同胞的HI抗体滴度水平无统计学差异。健康对照者的老年组中麻疹HI滴度显著下降，而在多发性硬化症组中未发现类似下降。血清HI抗体滴度水平与多发性硬化症患者的性别或疾病活动度无关。在6例多发性硬化症患者的脑脊液中检测到低滴度的HI抗体，而8例对照患者的脑脊液中均未检测到可测量的麻疹抗体痕迹。简要讨论了这些发现对多发性硬化症病因学的意义。
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