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Structure of a dinucleotide: thymidylyl-(5'-3')-thymidylate-5' (pTpT).
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脱氧核糖三磷酸二核苷酸在水溶液中的空间构型。

Spatial configuration of deoxyribotrinucleoside diphosphates in aqueous solution.

作者信息

Cheng D M, Dhingra M M, Sarma R H

出版信息

Nucleic Acids Res. 1978 Nov;5(11):4399-416. doi: 10.1093/nar/5.11.4399.

DOI:10.1093/nar/5.11.4399
PMID:724520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342757/
Abstract

The detailed conformational features and dynamics of the naturally occurring deoxyribotrinucleoside diphosphates d-TpTpT and d-TpTpC have been investigated at 20 degrees C and 80 degrees C in aqueous solution by nuclear magnetic resonance spectroscopy. The observed NMR parameters indicate that the conformational properties of the trimers are very similar to those of the constituent dimers and monomers, i.e., the monomers and dimers conserve their intrinsic conformational features when they become incorporated into oligomers. Model building indicate that the distant shieldings can originate from spatial configurations in which the central nucleotidyl unit is bulged out and the w'1w1, w'2w2 occupy /g+g+, g+g+/ domains.

摘要

通过核磁共振光谱法，在20摄氏度和80摄氏度的水溶液中研究了天然存在的脱氧核糖三磷酸核苷d-TpTpT和d-TpTpC的详细构象特征和动力学。观察到的核磁共振参数表明，三聚体的构象性质与组成二聚体和单体的构象性质非常相似，即单体和二聚体在并入寡聚体时保留其固有的构象特征。模型构建表明，远程屏蔽可能源于中心核苷酸单元凸出且w'1w1、w'2w2占据/g+g+，g+g+/区域的空间构型。