中枢神经系统内的抗体合成：脑脊液IgG指数与电泳的比较
Antibody synthesis within the central nervous system: comparisons of CSF IgG indices and electrophoresis.
作者信息
Thompson E J, Riches P G, Kohn J
出版信息
J Clin Pathol. 1983 Mar;36(3):312-5. doi: 10.1136/jcp.36.3.312.
Abstract
VARIOUS LABORATORIES HAVE REPORTED DIFFERING SUCCESS RATES IN THEIR ABILITY TO DETECT INTRATHECAL SYNTHESIS OF ANTIBODY WHEN COMPARING THE INDEX OF [FORMULA: see text] with electrophoretic analysis. We selected 44 patients in the borderline area of minimal and/or equivocal abnormality by IgG index. Electrophoretic analysis (on polyacrylamide gels for oligoclonal gamma globulin pattern) of parallel specimens was performed at the same time. The number of samples giving a normal index but showing oligoclonal bands varied between 34% and 43% depending on the cut-off point. The views about normal barrier functions underlying such indices are discussed with particular reference to the pathophysiology of the blood-CSF barrier.
摘要
在比较[公式：见正文]指数与电泳分析时，各实验室报告其检测鞘内抗体合成能力的成功率各不相同。我们根据IgG指数选择了44例处于最小和/或可疑异常临界区域的患者。同时对平行样本进行电泳分析（在聚丙烯酰胺凝胶上检测寡克隆γ球蛋白模式）。根据截断点的不同，指数正常但显示寡克隆带的样本数量在34%至43%之间变化。本文特别参照血脑屏障的病理生理学，讨论了关于这些指数所依据的正常屏障功能的观点。
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