Davies J, Courvalin P
Am J Med. 1977 Jun;62(6):868-72. doi: 10.1016/0002-9343(77)90654-4.
Bacterial resistance to aminoglycoside antibiotics occurs by a variety of mechanisms. In clinical situations the most common mechanism is plasmid-determined modification of the drug that leads to a block of transport of the antibiotic into the cell. Amikacin, a semisynthetic aminoglycoside, is effective against a number of resistant strains because it has fewer sites of modification.
细菌对氨基糖苷类抗生素产生耐药性的机制多种多样。在临床情况下，最常见的机制是由质粒决定的药物修饰，这会导致抗生素进入细胞的转运受阻。阿米卡星是一种半合成氨基糖苷类抗生素，对许多耐药菌株有效，因为它的修饰位点较少。
