大鼠肝脏体内线粒体和胞质中的ATP/ADP比率
Mitochondrial and cytosolic ATP/ADP ratios in rat liver in vivo.
作者信息
Schwenke W D, Soboll S, Seitz H J, Sies H
出版信息
Biochem J. 1981 Nov 15;200(2):405-8. doi: 10.1042/bj2000405.
Abstract
The ratio of ATP content/ADP content in livers from unanaesthetized fed rat was 0.9 in the mitochondrial matrix and 6.9 in the cytosol; the values for starved (48 h) animals were 1.0 and 5.9 respectively. The mitochondrial ratios observed in unanaesthetized animals were higher than in haemoglobin-free-perfused liver and lower than in isolated hepatocytes. Possible reasons for these differences may be related to oxygen supply and/or other factors. Further, data from anaesthetized rats with the liver exposed are given: mitochondrial ATP/ADP ratios were decreased with pentobarbital, but less so with ketamine as narcotic agent.
摘要
未麻醉的喂食大鼠肝脏线粒体基质中ATP含量与ADP含量的比值为0.9，胞质溶胶中为6.9；饥饿（48小时）动物的相应值分别为1.0和5.9。未麻醉动物中观察到的线粒体比值高于无血红蛋白灌注的肝脏，低于分离的肝细胞。这些差异的可能原因可能与氧气供应和/或其他因素有关。此外，还给出了肝脏暴露的麻醉大鼠的数据：戊巴比妥可降低线粒体ATP/ADP比值，但氯胺酮作为麻醉剂时降低幅度较小。
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