Hakulinen T, Salonen T, Teppo L
Br J Prev Soc Med. 1976 Jun;30(2):138-40. doi: 10.1136/jech.30.2.138.
A case-control study has been conducted to see whether a hydrocarbon-related occupation of the father at the time of conception constitutes a risk factor for malignant disease in the offspring. The series comprised 852 cancer cases from the Finnish Cancer Registry and 852 controls matched for date of birth and domicile. The father's occupation for both the cases and controls was ascertained from the records of antenatal clinics. No significant associations were found between the commonest types of childhood cancer and hydrocarbon-related occupations--that is, motor-vehicle mechanics, machinists, miners, painters, and motor-vehicle drivers. Risk ratio 2 was excluded from most of the 95% confidence intervals for children under 15 years of age. The results do not support the hypothesis that there is an excess risk of cancer in the children of fathers in hydrocarbon-related occupations.
已经开展了一项病例对照研究，以探究受孕时父亲从事与碳氢化合物相关的职业是否构成后代患恶性疾病的风险因素。该研究系列包括来自芬兰癌症登记处的852例癌症病例以及852名在出生日期和住所方面与之匹配的对照。病例组和对照组父亲的职业均从产前诊所记录中确定。未发现儿童期最常见癌症类型与从事碳氢化合物相关职业（即机动车机械师、机械师、矿工、油漆工和机动车驾驶员）之间存在显著关联。15岁以下儿童的大多数95%置信区间排除了风险比为2的情况。研究结果不支持如下假设：从事与碳氢化合物相关职业的父亲所生育的子女患癌症风险更高。
