Rutqvist L, Björklund N E, Hult K, Hökby E, Carlsson B
Appl Environ Microbiol. 1978 Dec;36(6):920-5. doi: 10.1128/aem.36.6.920-925.1978.
At a number of slaughters nephropathy and high ochratoxin A contents in kidneys have been observed in fattening pigs from two Swedish farms. In one herd the source of contamination was barley grown on the home farm and stored under such conditions that the growth of fungal species (Penicillium verrucosum var. verrucosum) producing ochratoxin A occurred, with the subsequent formation of the toxin. In this case high ochratoxin A levels in fattening pigs were found during a period of about 18 months. In the second herd, where compounded feed was used, it was impossible to locate the source of contamination. It was presumed that a consignment of feed was damaged by rain during storage at the farm. Ochratoxin A was found in fattening pigs from this herd for a period of about 2 months. Ochratoxin A appeared in the kidneys of all investigated pigs. In some animals the livers, whole blood, and plasma were analyzed, too. The livers contained somewhat lower amounts of ochratoxin A than the kidneys, whereas the content in whole blood and plasma, respectively, was 5 and 13 times greater. Kidneys spontaneously contaminated with ochratoxin A, when stored for 10 months at -70 degrees C, showed no systematic decrease in toxin content.
在瑞典的两个农场中，人们在育肥猪的屠宰过程中观察到了肾病以及肾脏中赭曲霉毒素A含量过高的情况。在其中一个猪群中，污染源是自家农场种植的大麦，大麦在储存时条件不佳，导致产生赭曲霉毒素A的真菌物种（疣孢青霉疣孢变种）生长，随后毒素形成。在这种情况下，大约18个月的时间里育肥猪体内的赭曲霉毒素A含量一直很高。在第二个猪群中，使用的是混合饲料，无法确定污染源。据推测，一批饲料在农场储存期间被雨水损坏。在这个猪群的育肥猪中，大约2个月的时间里都检测到了赭曲霉毒素A。所有接受调查的猪的肾脏中都出现了赭曲霉毒素A。对一些动物的肝脏、全血和血浆也进行了分析。肝脏中的赭曲霉毒素A含量略低于肾脏，而全血和血浆中的含量分别比肾脏高5倍和13倍。被赭曲霉毒素A自然污染的肾脏，在-70摄氏度下储存10个月后，毒素含量没有系统性下降。
