Rurangirwa F R, Tabel H, Losos G J, Tizard I R
Tropenmed Parasitol. 1980 Mar;31(1):105-10.
Cattle infected with Trypanosoma congolense were intravenously immunized with Leptospira biflexa 15 days after trypanosomal infection. The primary immune response to L. biflexa was considerably reduced as compared to uninfected controls. The infected cattle mounted a secondary response when they were cured of trypanosomes by treatment with Berenil 25 days after infection and re-immunized 8 days later. The mean secondary response in these previously infected animals was lower tha, but not significantly different from that of the uninfected control animals. Serum collected 15, 20 and 25 days after infection was inhibitory to the migration of both autologous and isologous (control) peripheral blood leucocytes. The migration inhibitory activity was abolished by heating the serum at 56 degrees C for 30 minutes implying the involvement of a heat labile serum component(s). The same serum did not modify the mitogenic effect of PHA on autologous peripheral lymphocytes.
感染刚果锥虫的牛在锥虫感染15天后用双曲钩端螺旋体进行静脉免疫。与未感染的对照相比，对双曲钩端螺旋体的初次免疫反应显著降低。感染的牛在感染后25天用贝尼尔治疗治愈锥虫并在8天后再次免疫时产生了二次反应。这些先前感染动物的平均二次反应低于未感染对照动物，但无显著差异。感染后15、20和25天收集的血清对自体和同种（对照）外周血白细胞的迁移具有抑制作用。通过将血清在56℃加热30分钟，迁移抑制活性被消除，这意味着涉及一种热不稳定的血清成分。相同的血清并未改变PHA对自体外周淋巴细胞的促有丝分裂作用。
