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采用氮选择性检测的毛细管气液色谱法测定大鼠血浆中的HA - 966。

Assay of HA-966 in rat plasma by capillary gas-liquid chromatography with nitrogen-selective detection.

作者信息

Broxterman H J, Noach E L, de Vos D

出版信息

J Chromatogr. 1980 Aug 8;183(2):185-91. doi: 10.1016/s0378-4347(00)81692-8.

DOI:10.1016/s0378-4347(00)81692-8
PMID:7400277
Abstract

A gas-liquid chromatographic method for the determination of the gamma-aminobutyric acid-like drug 1-hydroxy-3-aminopyrrolidone-2 (HA-966) in plasma is described. HA-966 was converted into its diacetyl derivative AC2HA-966 with acetic anhydride. This compound could be suitable eluted from a capillary OV-17 support-coated open tubular column. A sensitive detection method was achieved by making use of nitrogen-phosphorus-selective flame ionization.

摘要

描述了一种用于测定血浆中γ-氨基丁酸样药物1-羟基-3-氨基吡咯烷-2（HA-966）的气-液色谱法。HA-966用乙酸酐转化为其二乙酰衍生物AC2HA-966。该化合物可从毛细管OV-17载体涂渍空心柱上得到合适的洗脱。利用氮磷选择性火焰离子化实现了一种灵敏的检测方法。

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