McKendrick M W, Gully P R, Geddes A M
Br Med J. 1980 Nov 22;281(6252):1390-1. doi: 10.1136/bmj.281.6252.1390.
Review of all 126 children admitted to the communicable diseases unit with whooping cough during the epidemic in 1978 showed that two had received two doses of triple vaccine and only one had had full primary immunisation against the disease. None of these three children suffered complications of the disease. Of the 123 children who had not been immunised against pertussis, however, 66 had had one or more complications. In Birmingham the dramatic decline in immunisation against pertussis has been accompanied by a fall in acceptance rates for diphtheria and tetanus immunization. Nevertheless, of the 62 children aged over 1 year in this series, 41 had been so immunised. These findings suggest that the apparently positive decision by parents to omit pertussis immunisation was misplaced, since immunisation does protect against the more serious complications of the disease. Furthermore, there is no firm evidence that pertussis immunisation of children without specific contraindications is associated with serious adverse reactions.
对1978年疫情期间收治到传染病科的126名患百日咳儿童的回顾显示，其中2名儿童接种过两剂三联疫苗，仅1名儿童完成了针对该疾病的全程基础免疫。这3名儿童均未出现该疾病的并发症。然而，在123名未接种过百日咳疫苗的儿童中，66名出现了一种或多种并发症。在伯明翰，百日咳免疫接种率的急剧下降伴随着白喉和破伤风免疫接种接受率的下降。尽管如此，在本系列研究的62名1岁以上儿童中，41名已接种了此类疫苗。这些发现表明，家长们明显做出的不进行百日咳免疫接种的决定是错误的，因为免疫接种确实可以预防该疾病更严重的并发症。此外，没有确凿证据表明对无特定禁忌证的儿童进行百日咳免疫接种会引发严重不良反应。
