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Z-DNA 内反应位点的静电势和空间可及性。

The electrostatic potential and steric accessibility of reactive sites within Z-DNA.

作者信息

Zakrzewska K, Lavery R, Pullman A, Pullman B

出版信息

Nucleic Acids Res. 1980 Sep 11;8(17):3917-32. doi: 10.1093/nar/8.17.3917.

Abstract

A theoretical study of indices potentially useful for investigation of the reactivity of the recently discovered Z-DNA double helix is presented. The electrostatic potential minima and the steric accessibility of reactive sites are calculated. The effect of screening the phosphate groups by metal cations is investigated. The results are compared with those for the B-DNA double helix.

摘要

本文对可能有助于研究最近发现的Z-DNA双螺旋反应活性的指标进行了理论研究。计算了静电势极小值和反应位点的空间可及性。研究了金属阳离子对磷酸基团的屏蔽作用。并将结果与B-DNA双螺旋的结果进行了比较。

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本文引用的文献

1
Left-handed DNA helices.
Nature. 1980 Feb 21;283(5749):743-5. doi: 10.1038/283743a0.
2
The electrostatic molecular potential of yeast tRNAPhe. (I). The potential due to the phosphate backbone.
Nucleic Acids Res. 1980 Mar 11;8(5):1061-79. doi: 10.1093/nar/8.5.1061.
4
Solvent accessibility study on tRNAPhe.
Biopolymers. 1979 Sep;18(9):2233-47. doi: 10.1002/bip.1979.360180911.
5
Molecular structure of a left-handed double helical DNA fragment at atomic resolution.
Nature. 1979 Dec 13;282(5740):680-6. doi: 10.1038/282680a0.

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