来自欧洲槲寄生（Viscum album L.）的一种有毒凝集素对蛋白质合成的抑制作用。
Inhibition of protein synthesis by a toxic lectin from Viscum album L. (mistletoe).
作者信息
Stirpe F, Legg R F, Onyon L J, Ziska P, Franz H
出版信息
Biochem J. 1980 Sep 15;190(3):843-5. doi: 10.1042/bj1900843.
Abstract
- The haemagglutinating and toxic lectin from Viscum album L. (mistletoe) inhibits protein synthesis in a lysate of rabbit reticulocytes, with an ID50 (concentration giving 50% inhibition) of 2.6 microgram/ml. This effect is enhanced (ID50 0.21 microgram/ml) if the lectin is reduced with 2-mercaptoethanol. 2. The lectin inhibits protein synthesis also in BL8L cells in culture. Inhibition occurs after a lag time of 3 h. The ID50 is 7 ng/ml, and increases after reduction of the lectin. 3. This and the gross lesions observed in rats poisoned with V. album lectin indicate this is a toxin very similar to ricin.
摘要
- 欧洲槲寄生（Viscum album L.）的血凝素和毒性凝集素可抑制兔网织红细胞裂解物中的蛋白质合成，半数抑制浓度（ID50）为2.6微克/毫升。如果用2-巯基乙醇还原该凝集素，这种作用会增强（ID50为0.21微克/毫升）。2. 该凝集素也可抑制培养的BL8L细胞中的蛋白质合成。抑制作用在3小时的延迟时间后出现。ID50为7纳克/毫升，凝集素还原后该值会增加。3. 这一点以及在用欧洲槲寄生凝集素中毒的大鼠身上观察到的严重损伤表明，这是一种与蓖麻毒素非常相似的毒素。
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