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本文引用的文献

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Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic-clonic seizure. First Seizure Trial Group (FIR.S.T. Group).
Neurology. 1993 Mar;43(3 Pt 1):478-83. doi: 10.1212/wnl.43.3_part_1.478.
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Standard approach to antiepileptic drug treatment in the United Kingdom.
Epilepsia. 1994;35 Suppl 4:S3-10. doi: 10.1111/j.1528-1157.1994.tb05954.x.
3
Indication for computed tomography of the brain in patients with first uncomplicated generalised seizure.首次单纯性全身性癫痫发作患者的脑部计算机断层扫描指征。
BMJ. 1994 Oct 15;309(6960):986-9. doi: 10.1136/bmj.309.6960.986.
4
Do anticonvulsants alter the natural course of epilepsy? Treatment should be started as early as possible.抗惊厥药会改变癫痫的自然病程吗?治疗应尽早开始。
BMJ. 1995 Jan 21;310(6973):176-7. doi: 10.1136/bmj.310.6973.176.
5
Value of computed tomographic scan in the evaluation of adult patients after their first seizure.计算机断层扫描在首次发作后成年患者评估中的价值。
Ann Neurol. 1984 Jun;15(6):536-43. doi: 10.1002/ana.410150605.
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Is routine computerised axial tomography in epilepsy worth while?
Lancet. 1982 Dec 25;2(8313):1446-7. doi: 10.1016/s0140-6736(82)91340-x.
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Late-onset epilepsy: etiologies, types of seizure, and value of clinical investigation, EEG, and computerized tomography scan.
Epilepsia. 1985 May-Jun;26(3):227-31. doi: 10.1111/j.1528-1157.1985.tb05410.x.
8
The first seizure in adult life. Value of clinical features, electroencephalography, and computerised tomographic scanning in prediction of seizure recurrence.
Lancet. 1988 Apr 2;1(8588):721-6. doi: 10.1016/s0140-6736(88)91535-8.
9
Prognosis after a first untreated tonic-clonic seizure.首次未经治疗的强直阵挛性发作后的预后。
Lancet. 1985 Oct 5;2(8458):752-3. doi: 10.1016/s0140-6736(85)90631-2.
10
Seizure recurrence after a 1st unprovoked seizure: an extended follow-up.首次无诱因发作后的癫痫复发:长期随访
Neurology. 1990 Aug;40(8):1163-70. doi: 10.1212/wnl.40.8.1163.

我们如何处理成人的首次癫痫发作?

How do we manage the first seizure in adults?

作者信息

Edmondstone W M

机构信息

Royal Naval Hospital, Gosport.

出版信息

J R Coll Physicians Lond. 1995 Jul-Aug;29(4):289-94.

PMID:7473322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5401334/
Abstract

This paper reports an audit of the management of a first generalised seizure in a small district general hospital and describes the management policies of 95 general physicians and 82 neurologists. The audit studied 56 patients who presented in 1990-93 after witnessed generalised convulsions without focal neurological signs or previous history of seizures. Their ages ranged from 16 to 89 (mean 38) and 47 of them were men. In 31% alcohol was incriminated in the seizure. Blood tests were done in most patients but gave little useful information. Skull and chest radiographs were taken in fewer patients but were unhelpful. An electroencephalogram was done in 77% but failed to influence management in any, and only 2 of the 50 computed tomography scans performed led to a change in management. Only 21% received the correct advice about driving. A questionnaire sent to 130 general physicians and 109 neurologists sought their policy on the management of patients after a first generalised seizure. Completed forms were received from 95 physicians and 82 neurologists (response rate 74%). Half of physicians and neurologists perform a computed tomogram on all patients while one-third scan patients only above a certain age. Neurologists perform significantly more electroencephalograms (86% vs 65%) while many more physicians order a chest radiograph (73% vs 16%). About 80% of physicians compared with about 30% of neurologists ask for routine blood tests of haematology and biochemistry. Only 4% of physicians and 1% of neurologists routinely start anticonvulsant treatment.

摘要

本文报告了一家小型地区综合医院对首次全身性癫痫发作管理情况的审计,并描述了95名普通内科医生和82名神经科医生的管理政策。该审计研究了1990年至1993年间出现全身性惊厥且无局灶性神经体征或癫痫发作史的56例患者。他们的年龄在16岁至89岁之间(平均38岁),其中47人为男性。31%的患者癫痫发作与酒精有关。大多数患者进行了血液检查,但提供的有用信息很少。较少患者进行了颅骨和胸部X光检查,但并无帮助。77%的患者进行了脑电图检查,但对治疗管理均无影响,50例计算机断层扫描中只有2例导致了治疗管理的改变。只有21%的患者得到了关于驾驶的正确建议。向130名普通内科医生和109名神经科医生发送了一份问卷,询问他们对首次全身性癫痫发作后患者的管理政策。收到了95名医生和82名神经科医生填写的表格(回复率74%)。一半的医生和神经科医生对所有患者进行计算机断层扫描,而三分之一的医生仅对特定年龄以上的患者进行扫描。神经科医生进行脑电图检查的比例显著更高(86%对65%),而更多的医生开具胸部X光检查(73%对16%)。约80%的医生要求进行血液学和生化常规血液检查,而神经科医生这一比例约为30%。只有4%的医生和1%的神经科医生常规开始抗惊厥治疗。