类风湿关节炎中血清补体B因子的代谢
Metabolism of factor B of serum complement in rheumatoid arthritis.
作者信息
Krick E H, De Heer D H, Kaplan R A, Arroyave C M, Vaughan J H
出版信息
Clin Exp Immunol. 1978 Oct;34(1):1-9.
An increased rate of catabolism of radio-iodinated Factor B has been shown in five out of ten patients with rheumatoid arthritis. Serum levels of Factor B were normal, the increased catabolism being matched by increased synthesis. The patients showing high catabolic rates had more manifestations of extra articular disease than did those with normal catabolic rates and they had higher rheumatoid factor titres. In seven patients, the catabolic rate for Factor B correlated significantly with the rate of IgG catabolism. In this series, the Raji-cell assay for immune complex-like material was in the normal or near normal range in all but one patient.
在10例类风湿性关节炎患者中，有5例的放射性碘化B因子分解代谢率升高。B因子的血清水平正常，分解代谢增加与合成增加相匹配。分解代谢率高的患者比分解代谢率正常的患者有更多关节外疾病表现，且类风湿因子滴度更高。在7例患者中，B因子的分解代谢率与IgG分解代谢率显著相关。在该系列研究中，除1例患者外，所有患者的免疫复合物样物质的Raji细胞检测均在正常或接近正常范围内。
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