Zilov V G, Patyshakuliev A P
Vestn Ross Akad Med Nauk. 1994(1):42-5.
The present investigation was undertaken to examine the neurochemical mechanisms of the modulatory effect of substance P (SP) on feeding behavior induced by threshold electrical stimulation of the lateral hypothalamus (LH) in rabbits. The administration of SP, 15 nmol, was found to transform feeding induced by stimulation of LH into escape. The phenomenon was shown to begin at min 20, and to last up to min 60 after SP injection. In the experiments, some antagonists of classic neurotransmitters were injected into the marginal vein of the rabbit ear. An important role of catecholaminergic and M-cholinergic formations in the brain in the SP transformation of their feeding behavior into escape was found in electric stimulation of LH. H-cholinergic and GABA-ergic antagonists produced no effect on the modulatory effect of SP.
本研究旨在探讨P物质（SP）对家兔下丘脑外侧区（LH）阈下电刺激诱导的摄食行为调节作用的神经化学机制。发现给予15 nmol的SP可使LH刺激诱导的摄食转变为逃避。该现象在注射SP后20分钟开始出现，并持续至60分钟。在实验中，将一些经典神经递质拮抗剂注入家兔耳缘静脉。在LH电刺激中发现，脑内儿茶酚胺能和M胆碱能结构在SP将其摄食行为转变为逃避行为中起重要作用。H胆碱能和GABA能拮抗剂对SP的调节作用无影响。
