Broekroelofs J, Mulder A H, Nelis G F, Westerveld B D, Tervaert J W, Kallenberg C G
Department of Gastroenterology, Sophia Hospital, Zwolle.
Dig Dis Sci. 1994 Mar;39(3):545-9. doi: 10.1007/BF02088340.
Anti-neutrophil cytoplasmic antibodies producing a perinuclear fluorescence pattern on ethanol-fixed granulocytes (p-ANCA) were found in 33 of 67 patients (49%) with ulcerative colitis (UC) but also in 14 of 35 patients (40%) with Crohn's disease (CD). In the latter condition p-ANCA were equally present in subgroups with colonic, ileocolonic, or ileal involvement only. Titers of p-ANCA were higher in patients with UC compared to CD patients, in particular when comparing patients with active disease. In contrast to findings in CD, patients with active UC had higher titers of p-ANCA than patients with inactive UC. Although p-ANCA were incidentally directed to lactoferrin, both in UC and CD, and to proteinase-3 and myeloperoxidase in UC only, the antigenic nature of p-ANCA could not be identified in most of the cases. We conclude that, within the spectrum of inflammatory bowel disease, the presence of p-ANCA is not specific for UC. When titers of p-ANCA are taken into account, the presence of high-titered p-ANCA, however, suggests active UC.
在67例溃疡性结肠炎（UC）患者中，有33例（49%）在乙醇固定的粒细胞上产生核周荧光模式的抗中性粒细胞胞浆抗体（p-ANCA）；而在35例克罗恩病（CD）患者中，也有14例（40%）出现这种情况。在CD患者中，仅累及结肠、回结肠或回肠的亚组中p-ANCA的出现情况相同。与CD患者相比，UC患者的p-ANCA滴度更高，尤其是在比较活动期疾病患者时。与CD患者的情况相反，活动期UC患者的p-ANCA滴度高于非活动期UC患者。虽然在UC和CD患者中，p-ANCA偶尔会针对乳铁蛋白，在UC患者中还会针对蛋白酶-3和髓过氧化物酶，但在大多数情况下，无法确定p-ANCA的抗原性质。我们得出结论，在炎症性肠病范围内，p-ANCA的存在并非UC所特有。然而，考虑到p-ANCA的滴度，高滴度p-ANCA的存在提示为活动期UC。
