Uehara S, Abe Y, Saito T, Yoshida Y, Wagatsuma S, Okamura K, Yajima A, Mandai M
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
Tohoku J Exp Med. 1993 Nov;171(3):195-202. doi: 10.1620/tjem.171.195.
This study was undertaken to clarify the incidence of the vertical transmission of hepatitis C virus (HCV). During the third trimester, 2015 pregnant women were examined as to anti-HCV antibodies. Anti-HCV antibody seropositive women were examined for HCV-RNA in peripheral blood at labor and in breast milk. Their offspring were also examined for HCV-RNA in umbilical cord blood and peripheral blood one week after birth and during subsequent outpatient visits. The following results were obtained: (1) Twelve of the 2015 pregnant women (0.6%) were seropositive for anti-HCV antibodies; (2) Seven of the twelve women (58%) seropositive for anti-HCV antibodies were also seropositive for HCV-RNA; (3) Three newborns of the seven HCV-RNA seropositive women (43%) were found to have HCV-RNA in the cord blood; (4) In the three newborns HCV-RNA had disappeared from the peripheral blood within one month after birth; (5) Two of the seven HCV-RNA seropositive women (29%) had HCV-RNA positive breast milk; (6) The possibility of infection via breast milk was shown in one infant at ten months after birth. Based on these results, it is indicated that HCV vertical transmission is possible in more than half of the HCV-RNA seropositive mothers. However, because of the disappearance of HCV from the infants' peripheral blood, further following study is needed.
本研究旨在阐明丙型肝炎病毒（HCV）垂直传播的发生率。在妊娠晚期，对2015名孕妇进行了抗HCV抗体检测。抗HCV抗体血清学阳性的女性在分娩时和母乳中检测外周血中的HCV-RNA。她们的后代在出生后一周及随后的门诊就诊时也检测脐带血和外周血中的HCV-RNA。获得了以下结果：（1）2015名孕妇中有12名（0.6%）抗HCV抗体血清学阳性；（2）12名抗HCV抗体血清学阳性的女性中有7名（58%）HCV-RNA也呈阳性；（3）7名HCV-RNA血清学阳性女性中的3名新生儿（43%）脐带血中检测到HCV-RNA；（4）3名新生儿出生后1个月内外周血中的HCV-RNA消失；（5）7名HCV-RNA血清学阳性女性中有2名（29%）母乳中HCV-RNA呈阳性；（6）1名婴儿在出生后10个月时显示出经母乳感染的可能性。基于这些结果，表明超过一半的HCV-RNA血清学阳性母亲可能发生HCV垂直传播。然而，由于婴儿外周血中HCV消失，需要进一步的后续研究。
