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酯酶-17（ES-17）：家鼠（小家鼠）对磷酸双对硝基苯酯抗性酯酶的特性及在9号染色体上的基因定位

Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus).

作者信息

Otto J, von Deimling O H

出版信息

Biochem Genet. 1983 Feb;21(1-2):37-48. doi: 10.1007/BF02395390.

DOI:10.1007/BF02395390
PMID:6838491
Abstract

Genetic variation of a new codominantly inherited esterase, designated ES-17, has been discovered in the house mouse using isoelectric focusing in polyacrylamide gels. The ES-17 A phenotype (three bands; isoelectric points, between pH 5.55 and pH 5.90) was found in C57BL/10Sn. LP/J possessed the Es-17B phenotype (three bands; isoelectric points, pH 5.05-5.55). ES-17 was present in all tissues examined, except for hemolysate and serum, and was most clearly expressed in the small intestine. Because of its reaction toward various substrates and inhibitors, ES-17 has tentatively been classified as acetyl esterase (EC 3.1.1.6). ES-17 was shown to be controlled by the structural locus Es-17, located on chromosome 9. From test-cross data, a gene order of Es-17-8.7 +/- 2.5 map units-Mpi-1-10.2 +/- 2.7 map units-Mod-1 was established.

摘要

利用聚丙烯酰胺凝胶等电聚焦技术，在家鼠中发现了一种新的共显性遗传酯酶ES - 17的遗传变异。在C57BL/10Sn小鼠中发现了ES - 17 A表型（三条带；等电点在pH 5.55至pH 5.90之间）。LP/J小鼠具有Es - 17B表型（三条带；等电点，pH 5.05 - 5.55）。除溶血产物和血清外，ES - 17存在于所有检测的组织中，且在小肠中表达最为明显。由于其对各种底物和抑制剂的反应，ES - 17暂时被归类为乙酰酯酶（EC 3.1.1.6）。研究表明ES - 17受位于9号染色体上的结构基因座Es - 17控制。根据测交数据，确定了基因顺序为Es - 17 - 8.7 ± 2.5个图距单位 - Mpi - 1 - 10.2 ± 2.7个图距单位 - Mod - 1。

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Esterase-17 (ES-17): characterization and genetic location on chromosome 9 of a bis-p-nitrophenyl phosphate-resistant esterase of the house mouse (Mus musculus).酯酶-17（ES-17）：家鼠（小家鼠）对磷酸双对硝基苯酯抗性酯酶的特性及在9号染色体上的基因定位
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引用本文的文献

1
The non-specific esterases of mouse lung.小鼠肺的非特异性酯酶
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2
Lengths of chromosomal segments conserved since divergence of man and mouse.自人类和小鼠分化以来保守的染色体片段长度。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):814-8. doi: 10.1073/pnas.81.3.814.
3
Nonspecific esterases of mammalian testis. Comparative studies on the mouse (Mus musculus) and rat (rattus norvegicus).哺乳动物睾丸的非特异性酯酶。小鼠（小家鼠）和大鼠（褐家鼠）的比较研究。

本文引用的文献

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Indigogenic staining methods for esterases.酯酶的靛基质生成染色法。
Gen Cytochem Methods. 1958;1:375-98.
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Esterase-16 (es-16): characterization, polymorphism, and linkage to chromosome 3 of a kidney esterase locus of the house mouse.酯酶-16（es-16）：家鼠肾脏酯酶基因座的特性、多态性及与3号染色体的连锁关系
Biochem Genet. 1981 Dec;19(11-12):1091-9. doi: 10.1007/BF00484567.
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Comparative map for mice and humans.小鼠与人类的比较图谱。
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Mouse map of paralogous genes.同源基因的小鼠图谱。
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Mouse chromosome 9.小鼠9号染色体。
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Mouse chromosome 9.小鼠9号染色体。
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Linkage among esterase-6 (Es-6), neural cell adhesion molecule (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8.大鼠8号染色体上酯酶-6（Es-6）、神经细胞黏附分子（NCAM）和载脂蛋白C-III（apoc-3）基因之间的连锁关系。
Mamm Genome. 1992;3(11):656-8. doi: 10.1007/BF00352485.
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Comparative map for mice and humans.小鼠与人类的比较图谱。
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Biochem Genet. 1982 Apr;20(3-4):221-8. doi: 10.1007/BF00484420.
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Linkage analyses using biochemical variants in mice. 3. Linkage relationships of eleven biochemical markers.利用小鼠生化变异进行连锁分析。3. 11种生化标记的连锁关系。
Biochem Genet. 1970 Apr;4(2):339-50. doi: 10.1007/BF00485782.
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Polymorphism and linkage for mannosephosphate isomerase in Mus musculus.小家鼠中磷酸甘露糖异构酶的多态性与连锁关系
Biochem Genet. 1973 Jan;8(1):47-53. doi: 10.1007/BF00485556.
6
Enzyme electrophoresis on cellulose acetate gel. II. Zymogram patterns in man-Chinese hamster somatic cell hybrids.醋酸纤维素凝胶上的酶电泳。II. 人 - 中国仓鼠体细胞杂种中的酶谱模式。
Humangenetik. 1974;25(3):189-201. doi: 10.1007/BF00281426.
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A preliminary genetic interpretation of the esterase isozymes of human tissues.人体组织酯酶同工酶的初步遗传学解释。
Ann Hum Genet. 1975 Jul;39(1):1-20. doi: 10.1111/j.1469-1809.1975.tb00103.x.
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Esterase 13, a new mouse esterase locus with recessive expression and its genetic location on chromosome 9.酯酶13，一个具有隐性表达的新小鼠酯酶基因座及其在9号染色体上的基因定位。
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Esterase-7, a common constituent of numerous mouse tissues.
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[2 new esterase loci Es-14 and Es-15 in mice (genus Muc L.) : characterization by different substrates and inhibitors].[小鼠（小家鼠属）中的两个新酯酶基因座Es-14和Es-15：通过不同底物和抑制剂进行表征]
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