Zimmermann H
Biozentrum, J.W. Goethe-Universität, Frankfurt am Main, Germany.
Trends Neurosci. 1994 Oct;17(10):420-6. doi: 10.1016/0166-2236(94)90016-7.
Strong evidence has been provided that ATP can act as a transmitter not only in smooth muscle but also in peripheral ganglia and in brain. The cloning and molecular identification of two putative ATP receptors supports the previously established pharmacological receptor classifications. This review places into perspective the evidence for ATP as a neural signalling substance by examining sites of storage, release and hydrolysis, as well as potential actions and targets. The action of ATP is related to that of the nucleoside adenosine, and the potential of additional nucleotides to function as neural messenger is examined briefly.
已有强有力的证据表明，ATP不仅可作为平滑肌中的递质，还可作为外周神经节和大脑中的递质。两种假定的ATP受体的克隆和分子鉴定支持了先前确立的药理学受体分类。本综述通过研究ATP的储存、释放和水解位点以及潜在作用和靶点，对ATP作为神经信号物质的证据进行了全面审视。ATP的作用与核苷腺苷的作用相关，本文还简要探讨了其他核苷酸作为神经信使发挥作用的可能性。
