Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins.
作者信息
LaCasse E C, Lefebvre Y A
机构信息
Department of Medicine, University of Ottawa, Loeb Institute for Medical Research, Ottawa Civic Hospital, Canada.
出版信息
Nucleic Acids Res. 1995 May 25;23(10):1647-56. doi: 10.1093/nar/23.10.1647.
Abstract
摘要
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本文引用的文献
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Proteins controlling the nuclear uptake of NF-kappa B, Rel and dorsal.控制核因子κB、Rel和背侧蛋白核摄取的蛋白质。
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Evidence that the hormone binding domain of steroid receptors confers hormonal control on chimeric proteins by determining their hormone-regulated binding to heat-shock protein 90.有证据表明，类固醇受体的激素结合结构域通过决定其与热休克蛋白90的激素调节结合，赋予嵌合蛋白激素调控能力。
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Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.聚（ADP - 核糖）聚合酶DNA结合域的过度产生会阻碍哺乳动物细胞中烷基化诱导的DNA修复合成。
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4
A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA.一种定位于细胞质的核蛋白特异性地干扰核蛋白的输入，但不影响U1小核核糖核酸（U1 snRNA）的输入。
J Cell Biol. 1993 Apr;121(2):229-40. doi: 10.1083/jcb.121.2.229.
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Mapping of a sequence essential for the nuclear transport of the Xenopus ribosomal transcription factor xUBF using a simple coupled translation-transport and acid extraction approach.利用一种简单的翻译-转运偶联及酸提取方法对非洲爪蟾核糖体转录因子xUBF核转运所需的一个序列进行定位。
DNA Cell Biol. 1993 Apr;12(3):275-81. doi: 10.1089/dna.1993.12.275.
6
Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.人类热休克基因的激活伴随着热休克转录因子HSF1的寡聚化、修饰及快速易位。
Mol Cell Biol. 1993 Apr;13(4):2486-96. doi: 10.1128/mcb.13.4.2486-2496.1993.
7
High affinity binding of TAR RNA by the human immunodeficiency virus type-1 tat protein requires base-pairs in the RNA stem and amino acid residues flanking the basic region.人类免疫缺陷病毒1型反式激活蛋白（tat蛋白）与反式激活应答元件（TAR）RNA的高亲和力结合需要RNA茎中的碱基对以及碱性区域侧翼的氨基酸残基。
J Mol Biol. 1993 Mar 5;230(1):90-110. doi: 10.1006/jmbi.1993.1128.
8
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.热休克因子1对热休克基因转录的激活涉及寡聚化、获得DNA结合活性以及核定位，并且在无应激条件下也可发生。
Mol Cell Biol. 1993 Mar;13(3):1392-407. doi: 10.1128/mcb.13.3.1392-1407.1993.
9
Overlapping domains of the heterochromatin-associated protein HP1 mediate nuclear localization and heterochromatin binding.异染色质相关蛋白HP1的重叠结构域介导核定位和异染色质结合。
J Cell Biol. 1993 Jan;120(2):291-9. doi: 10.1083/jcb.120.2.291.
10
The D domain of the thyroid hormone receptor alpha 1 specifies positive and negative transcriptional regulation functions.甲状腺激素受体α1的D结构域决定了正负转录调控功能。
J Biol Chem. 1993 Jan 25;268(3):2021-8.
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