Wenisch C, Parschalk B, Burgmann H, Looareesuwan S, Graninger W
Department of Infectious Diseases, University Hospital of Vienna, Austria.
J Clin Immunol. 1995 Mar;15(2):69-73. doi: 10.1007/BF01541734.
Apart from cellular immunity and immunopathology, various cytokines have been implicated in malaria-associated immunosuppression. In this study, serum levels of transforming growth factor-beta (TGF-beta) were determined with an enzyme-linked immunosorbent assay in 37 patients with acute Plasmodium falciparum malaria prior to, during, and after therapy and in 17 healthy controls in Bangkok, Thailand. Patients were treated with artesunate and mefloquine. TGF-beta serum levels were found decreased prior to treatment (14 +/- 11 pg/ml versus 63 +/- 15 pg/ml in healthy controls; P < 0.05). The serum concentrations of TGF-beta increased after initiation of treatment and were within normal range on day 21. Serum levels of both tumor necrosis factor-alpha (TNF-alpha) and soluble TNF-receptor 55 kDa were inversely correlated to serum levels of TGF-beta (r = -0.667 and r = -0.592, n = 37; respectively, P < 0.05 for both). No correlation between parasitemia and serum levels of TGF-beta could be found. The results are compatible with a decreased production and release, an enhanced clearance or utilization, or tissue accumulation of TGF-beta in acute P. falciparum malaria.
除细胞免疫和免疫病理学外，多种细胞因子也与疟疾相关的免疫抑制有关。在本研究中，采用酶联免疫吸附测定法测定了泰国曼谷37例急性恶性疟原虫疟疾患者在治疗前、治疗期间和治疗后的血清转化生长因子-β（TGF-β）水平，并与17名健康对照者进行了比较。患者接受青蒿琥酯和甲氟喹治疗。发现治疗前TGF-β血清水平降低（14±11 pg/ml，而健康对照者为63±15 pg/ml；P<0.05）。治疗开始后TGF-β血清浓度升高，在第21天处于正常范围内。肿瘤坏死因子-α（TNF-α）和可溶性TNF受体55 kDa的血清水平均与TGF-β血清水平呈负相关（r=-0.667和r=-0.592，n=37；两者P均<0.05）。未发现疟原虫血症与TGF-β血清水平之间存在相关性。这些结果与急性恶性疟原虫疟疾中TGF-β产生和释放减少、清除或利用增强或组织蓄积相符。
