OXA-7 β-内酰胺酶基因的分子特征分析
Molecular characterization of the OXA-7 beta-lactamase gene.
作者信息
Scoulica E, Aransay A, Tselentis Y
机构信息
Department of Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Faculty of Medicine, University of Crete, Heraklion-Crete, Greece.
出版信息
Antimicrob Agents Chemother. 1995 Jun;39(6):1379-82. doi: 10.1128/AAC.39.6.1379.
Abstract
The OXA-7 gene, which encodes an oxacillinase, was cloned from plasmid pMG202 of Escherichia coli isolate 7181 (A. A. Medeiros, M. Cohenford, and G. A. Jacoby, Antimicrob. Agents Chemother. 27:715-719, 1985) and sequenced. The nucleotide sequence of the OXA-7 gene was closely related to that of the OXA-10 (PSE-2) gene, with a derived amino acid sequence of the OXA-7 enzyme showing greater than 95% homology with those of OXA-10 and OXA-11.
摘要
编码一种苯唑西林酶的OXA-7基因，是从大肠杆菌分离株7181的质粒pMG202中克隆得到的（A. A. 梅代罗斯、M. 科恩福德和G. A. 雅各比，《抗菌剂与化疗》27:715 - 719，1985年）并进行了测序。OXA-7基因的核苷酸序列与OXA-10（PSE-2）基因的序列密切相关，OXA-7酶的推导氨基酸序列与OXA-10和OXA-11的氨基酸序列具有超过95%的同源性。
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