常见可变免疫缺陷（CVI）患者的CD4和CD4 CD45RO细胞分泌白细胞介素（IL-2和IL-4）的变化。
Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients.
作者信息
Ferrer J M, Iglesias J, Hernández M, Matamoros N
机构信息
Immunology Section, Hospital Son Dureta, Palma de Mallorca, Spain.
出版信息
Clin Exp Immunol. 1995 Nov;102(2):286-9. doi: 10.1111/j.1365-2249.1995.tb03779.x.
Abstract
The failure of B cells from CVI patients to secrete normal amounts of antibodies has been attributed either to an intrinsic B cell defect or to a lack of cooperation from T cells. In an attempt to improve the definition of the origin of this defect in one of the main cellular compartments, we studied the ability of helper CD4 cells and their CD4 CD45RO subpopulation from CVI patients to secrete interleukins (IL-2 and IL-4) in response to mitogen stimulation. We found that CD4 and CD4 CD45RO cells from some patients secrete abnormal amounts of interleukins (in general low levels of IL-2 and high levels of IL-4) upon stimulation with pokeweed mitogen (PWM). These irregularities may contribute to the defective differentiation of B cells in these patients.
摘要
常见可变免疫缺陷（CVI）患者的B细胞无法分泌正常量的抗体，这要么归因于B细胞内在缺陷，要么归因于T细胞缺乏协同作用。为了更好地界定这一缺陷在主要细胞区室之一中的起源，我们研究了CVI患者的辅助性CD4细胞及其CD4 CD45RO亚群在有丝分裂原刺激下分泌白细胞介素（IL-2和IL-4）的能力。我们发现，来自部分患者的CD4和CD4 CD45RO细胞在用商陆有丝分裂原（PWM）刺激后会分泌异常量的白细胞介素（一般IL-2水平低而IL-4水平高）。这些异常情况可能导致这些患者B细胞分化存在缺陷。
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本文引用的文献
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CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.在一部分常见变异型免疫缺陷患者中，CD40配体表达存在缺陷。
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Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens.普通可变免疫缺陷（CVI）患者的外周血淋巴细胞产生的白细胞介素-4、白细胞介素-2和干扰素-γ水平降低，但在有丝分裂原激活后能正常增殖。
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Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2.通过B细胞分泌IgM和IgG对抗IgM和白细胞介素-2的反应对常见可变免疫缺陷患者进行分类。
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