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常见可变免疫缺陷（CVI）患者的CD4和CD4 CD45RO细胞分泌白细胞介素（IL-2和IL-4）的变化。

Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients.

作者信息

Ferrer J M, Iglesias J, Hernández M, Matamoros N

机构信息

Immunology Section, Hospital Son Dureta, Palma de Mallorca, Spain.

出版信息

Clin Exp Immunol. 1995 Nov;102(2):286-9. doi: 10.1111/j.1365-2249.1995.tb03779.x.

DOI:10.1111/j.1365-2249.1995.tb03779.x
PMID:7586680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553419/
Abstract

The failure of B cells from CVI patients to secrete normal amounts of antibodies has been attributed either to an intrinsic B cell defect or to a lack of cooperation from T cells. In an attempt to improve the definition of the origin of this defect in one of the main cellular compartments, we studied the ability of helper CD4 cells and their CD4 CD45RO subpopulation from CVI patients to secrete interleukins (IL-2 and IL-4) in response to mitogen stimulation. We found that CD4 and CD4 CD45RO cells from some patients secrete abnormal amounts of interleukins (in general low levels of IL-2 and high levels of IL-4) upon stimulation with pokeweed mitogen (PWM). These irregularities may contribute to the defective differentiation of B cells in these patients.

摘要

常见可变免疫缺陷（CVI）患者的B细胞无法分泌正常量的抗体，这要么归因于B细胞内在缺陷，要么归因于T细胞缺乏协同作用。为了更好地界定这一缺陷在主要细胞区室之一中的起源，我们研究了CVI患者的辅助性CD4细胞及其CD4 CD45RO亚群在有丝分裂原刺激下分泌白细胞介素（IL-2和IL-4）的能力。我们发现，来自部分患者的CD4和CD4 CD45RO细胞在用商陆有丝分裂原（PWM）刺激后会分泌异常量的白细胞介素（一般IL-2水平低而IL-4水平高）。这些异常情况可能导致这些患者B细胞分化存在缺陷。

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1
Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients.常见可变免疫缺陷（CVI）患者的CD4和CD4 CD45RO细胞分泌白细胞介素（IL-2和IL-4）的变化。
Clin Exp Immunol. 1995 Nov;102(2):286-9. doi: 10.1111/j.1365-2249.1995.tb03779.x.
2
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本文引用的文献

1
Interleukin 10 and immune restoration in common variable immunodeficiency.白细胞介素10与常见变异型免疫缺陷中的免疫恢复
Lancet. 1993 Sep 18;342(8873):750-1.
2
Study of B and T cell phenotypes in blood from patients with common variable immunodeficiency (CVID).普通可变免疫缺陷（CVID）患者血液中B细胞和T细胞表型的研究。
Immunodeficiency. 1994;5(2):159-69.
3
CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.在一部分常见变异型免疫缺陷患者中，CD40配体表达存在缺陷。
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1099-103. doi: 10.1073/pnas.91.3.1099.
4
Interleukin 4 instructs uncommitted B lymphocytes to switch to IgG1 and IgE.白细胞介素4指导未分化的B淋巴细胞转换为IgG1和IgE。
Eur J Immunol. 1988 Jul;18(7):1073-7. doi: 10.1002/eji.1830180716.
5
Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.正常小鼠中辅助性T细胞1和2亚群的特征。负责产生白细胞介素-4和白细胞介素-5的辅助性T细胞以前体形式存在，在发育成分泌淋巴因子的细胞之前需要启动。
J Immunol. 1988 Nov 15;141(10):3445-55.
6
Interleukin (IL) 4 counteracts the helper effect of IL2 on antigen-activated human B cells.白细胞介素 (IL) 4可抵消IL2对抗原激活的人B细胞的辅助作用。
Eur J Immunol. 1989 Apr;19(4):765-9. doi: 10.1002/eji.1830190429.
7
B cell function in acquired "common-variable" hypogammaglobulinemia: proliferative responses to lymphokines.获得性“常见变异型”低丙种球蛋白血症中的B细胞功能：对淋巴因子的增殖反应。
Clin Immunol Immunopathol. 1989 May;51(2):196-204. doi: 10.1016/0090-1229(89)90019-6.
8
Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens.普通可变免疫缺陷（CVI）患者的外周血淋巴细胞产生的白细胞介素-4、白细胞介素-2和干扰素-γ水平降低，但在有丝分裂原激活后能正常增殖。
Clin Exp Immunol. 1989 Dec;78(3):334-40.
9
IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2).白细胞介素-6（B细胞刺激因子-2）对人B细胞分化促进作用的白细胞介素-2依赖性
J Immunol. 1990 Jan 15;144(2):562-9.
10
Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2.通过B细胞分泌IgM和IgG对抗IgM和白细胞介素-2的反应对常见可变免疫缺陷患者进行分类。
Clin Immunol Immunopathol. 1990 Aug;56(2):239-48. doi: 10.1016/0090-1229(90)90145-g.