Kelly R I, Pearse R, Bull R H, Leveque J L, de Rigal J, Mortimer P S
Department of Dermatology, St. Georges Hospital, London, U.K.
J Am Acad Dermatol. 1995 Nov;33(5 Pt 1):749-56. doi: 10.1016/0190-9622(95)91812-4.
Few studies have attempted to quantitatively assess in vivo changes in the microvasculature with age.
The objective was to assess in vivo structural and functional changes in the cutaneous microvasculature with aging and to analyze the contribution of the microvasculature to skin color.
Video capillaroscopy, in conjunction with fluorescein angiography, and laser-Doppler flowmetry were used to compare elderly and young normal volunteers. Skin color differences were assessed with a handheld color reflectance meter. A photoexposed site, the forehead, and the relatively photoprotected ventral forearm were studied to differentiate photoaging from chronologic aging.
Dermal papillary loops were significantly reduced in old skin compared with young skin (forehead by 40%; forearm by 37%). Horizontal vessels showed increased volume fraction in elderly forehead and forearm skin. Laser-Doppler studies demonstrated no significant differences between young and old skin; indeed, hyperemic responsiveness appeared more rapid in the elderly. Color measurements showed elderly skin, particularly in men, to be significantly darker and redder.
A marked loss in dermal nutritional vessel density and surface area for exchange is a feature of both chronologic aging and photoaging.
很少有研究试图定量评估随着年龄增长体内微血管的变化。
旨在评估随着衰老皮肤微血管的体内结构和功能变化，并分析微血管对皮肤颜色的影响。
使用视频毛细血管显微镜结合荧光素血管造影术以及激光多普勒血流仪对老年和年轻正常志愿者进行比较。用手持式颜色反射仪评估皮肤颜色差异。研究了光暴露部位（前额）和相对光保护的前臂腹侧，以区分光老化和自然老化。
与年轻皮肤相比，老年皮肤的真皮乳头袢明显减少（前额减少40%；前臂减少37%）。老年前额和前臂皮肤的水平血管体积分数增加。激光多普勒研究表明年轻和老年皮肤之间无显著差异；实际上，老年人的充血反应似乎更快。颜色测量显示老年皮肤，尤其是男性，明显更暗更红。
真皮营养血管密度和交换表面积的显著减少是自然老化和光老化的共同特征。
