串珠镰刀菌素，一种串珠镰刀菌NRRL 6322的代谢产物：纯化与毒性
Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity.
作者信息
Burmeister H R, Ciegler A, Vesonder R F
出版信息
Appl Environ Microbiol. 1979 Jan;37(1):11-3. doi: 10.1128/aem.37.1.11-13.1979.
Abstract
Fusarium moniliforme NRRL 6322 produced about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. The moniliformin was extracted from the grits with methanol, purified by preparative thin-layer chromatography, and crystallized from ether. The 50% lethal dose for chicken embryos was 2.8 microgram per egg. For 1-day-old chicks dosed with moniliformin by crop intubation and for female and male mice injected intraperitoneally, the 50% lethal doses were 5.4, 20.9, and 29.1 mg per kg of body weight, respectively. The toxin did not cause a reaction on mouse skin.
摘要
串珠镰刀菌NRRL 6322每千克玉米碎粒培养基可产生约600毫克可回收的串珠镰刀菌素（一种霉菌毒素代谢产物）。串珠镰刀菌素用甲醇从碎粒中提取，通过制备型薄层色谱法纯化，并用乙醚结晶。鸡胚的半数致死剂量为每枚蛋2.8微克。对于通过嗉囊插管给予串珠镰刀菌素的1日龄雏鸡以及腹腔注射的雌性和雄性小鼠，半数致死剂量分别为每千克体重5.4、20.9和29.1毫克。该毒素对小鼠皮肤未引起反应。
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