Lenzi G L, Jones T, Reid J L, Moss S
J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):59-62. doi: 10.1136/jnnp.42.1.59.
Twenty-two patients affected by idiopathic Parkinsonism were studied using the oxygen-15 inhalation technique. The production of labelled metabolic water was found to be decreased in the parietal cerebral cortex, indicating an impairment in oxidative metabolism. This metabolic defect was localised mainly to the parietal cortex of the affected hemispheres; in non-affected hemispheres of patients presenting with unilateral Parkinsonism, the uptake was normal. In contrast, regional blood flow was not significantly altered. It is possible that this metabolic impairment is caused by chronic deafferentation.
采用氧-15吸入技术对22例特发性帕金森病患者进行了研究。发现顶叶大脑皮质中标记代谢水的生成减少，表明氧化代谢受损。这种代谢缺陷主要定位于受影响半球的顶叶皮质；在单侧帕金森病患者的未受影响半球，摄取正常。相比之下，局部血流没有明显改变。这种代谢损害可能是由慢性传入神经阻滞引起的。
