Kennedy M A, Mellon V S, Caldwell G, Potgieter L N
Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville 37901-1071, USA.
J Am Anim Hosp Assoc. 1995 May-Jun;31(3):254-8. doi: 10.5326/15473317-31-3-254.
The virucidal activity of several disinfectants containing newer generation quaternary ammonium compounds (QACs) as their active ingredients was evaluated. Disinfectants were used at the manufacturers' recommended dilutions with isolates of feline herpesvirus, feline calicivirus, and canine parvovirus, and a contact time of 10 minutes at room temperature. Detoxification of virus/disinfectant solutions was done by dialysis prior to virus assay in cell cultures. Two of four disinfectants completely inactivated feline herpesvirus, and two significantly reduced the titer of this virus. None of the disinfectants that were tested completely inactivated feline calicivirus. Canine parvovirus was not inactivated significantly by any of the QAC disinfectants. Sodium hypochlorite completely inactivated all viruses.
对几种以新一代季铵化合物（QACs）作为活性成分的消毒剂的杀病毒活性进行了评估。消毒剂按照制造商推荐的稀释度，与猫疱疹病毒、猫杯状病毒和犬细小病毒的分离株一起使用，并在室温下接触10分钟。在细胞培养中进行病毒检测之前，通过透析对病毒/消毒剂溶液进行解毒。四种消毒剂中有两种能完全灭活猫疱疹病毒，另外两种能显著降低该病毒的滴度。所测试的消毒剂中没有一种能完全灭活猫杯状病毒。任何一种QAC消毒剂都不能显著灭活犬细小病毒。次氯酸钠能完全灭活所有病毒。
