链霉菌属KO-7888产生的新型抗生素恶唑啉B、C和D。

New antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888.

作者信息

Shiomi K, Arai N, Shinose M, Takahashi Y, Yoshida H, Iwabuchi J, Tanaka Y, Omura S

机构信息

Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1995 Jul;48(7):714-9. doi: 10.7164/antibiotics.48.714.

DOI:10.7164/antibiotics.48.714

PMID:7649873

Abstract

New antibiotics, phthoxazolins B, C and D were isolated from the fermentation broth of Streptomyces sp. KO-7888. They are geometrical isomers of 10-hydroxyphthoxazolin A. They showed selective antifungal activity against Phytophthora parasitica in vitro and modest herbicidal activity in a laboratory test, but the potencies were different among isomers.

摘要

新型抗生素邻苯恶唑啉B、C和D是从链霉菌属KO - 7888的发酵液中分离得到的。它们是10 - 羟基邻苯恶唑啉A的几何异构体。它们在体外对寄生疫霉表现出选择性抗真菌活性，在实验室测试中具有适度的除草活性，但不同异构体的效力有所不同。