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AKD-2A、B、C和D，链霉菌属OCU-42815产生的新型抗生素。分类学、发酵、分离、结构解析及生物活性

AKD-2A, B, C and D, new antibiotics from Streptomyces sp. OCU-42815. Taxonomy, fermentation, isolation, structure elucidation and biological activity.

作者信息

Akeda Y, Shibata K, Ping X, Tanaka T, Taniguchi M

机构信息

Faculty of Science, Osaka City University, Japan.

出版信息

J Antibiot (Tokyo). 1995 May;48(5):363-8. doi: 10.7164/antibiotics.48.363.

DOI:10.7164/antibiotics.48.363
PMID:7797436
Abstract

An antibiotic complex, AKD-2, was isolated from the mycelial cake of Streptomyces sp. OCU-42815. The lipophilic substances in this complex were further purified by a recycling HPLC procedure and were designated AKD-2A, C and D. AKD-2B was obtained as a mixture of AKD-2B1 and AKD-2B2. These substances were identified as monoglycerides having branched chain fatty acids and exhibited both antibacterial and antifungal activities.

摘要

从链霉菌属菌株OCU - 42815的菌丝饼中分离出一种抗生素复合物AKD - 2。该复合物中的亲脂性物质通过循环高效液相色谱法进一步纯化，分别命名为AKD - 2A、C和D。AKD - 2B是以AKD - 2B1和AKD - 2B2的混合物形式获得的。这些物质被鉴定为具有支链脂肪酸的甘油单酯，并具有抗菌和抗真菌活性。

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