Walder A D, Aitkenhead A R
University Department of Anaesthesia, Queen's Medical Centre, Nottingham.
Anaesthesia. 1995 Jul;50(7):654-6. doi: 10.1111/j.1365-2044.1995.tb15124.x.
Fifty ASA 1 or 2 patients scheduled to undergo major gynaecological surgery were allocated randomly to one of two groups. All patients received a standard anaesthetic regimen. Patients in group 1 received droperidol 1.25 mg given intravenously 20 min prior to the end of surgery and a patient-controlled analgesia infusion containing morphine 1 mg.ml-1 and droperidol 0.05 mg.ml-1. Patients in group 2 received cyclizine 50 mg by slow intravenous injection 20 min prior to the end of surgery and a patient-controlled analgesia infusion containing morphine 1 mg.ml-1 and cyclizine 2 mg.ml-1. Fifteen of 25 patients (60%) in group 1 and 18 (72%) of 25 in group 2 suffered no nausea or vomiting postoperatively. Two patients (8%) in group 1 and three (12%) in group 2 suffered severe postoperative nausea or vomiting. We conclude that cyclizine is as effective as droperidol in the prevention of postoperative nausea and vomiting when included in a patient-controlled analgesia infusion using morphine.
五十例计划接受大型妇科手术的美国麻醉医师协会（ASA）分级为1或2级的患者被随机分配到两组中的一组。所有患者均接受标准麻醉方案。第一组患者在手术结束前20分钟静脉注射1.25毫克氟哌利多，并接受含1毫克/毫升吗啡和0.05毫克/毫升氟哌利多的患者自控镇痛输注。第二组患者在手术结束前20分钟缓慢静脉注射50毫克赛克利嗪，并接受含1毫克/毫升吗啡和2毫克/毫升赛克利嗪的患者自控镇痛输注。第一组25例患者中有15例（60%）、第二组25例患者中有18例（72%）术后未出现恶心或呕吐。第一组有2例患者（8%）、第二组有3例患者（12%）出现严重术后恶心或呕吐。我们得出结论，当赛克利嗪被包含在使用吗啡的患者自控镇痛输注中时，其在预防术后恶心和呕吐方面与氟哌利多效果相同。
