Lowe N J, Wieder J M, Shorr N, Boxrud C, Saucer D, Chalet M
Skin Research Foundation of California, Santa Monica, USA.
Dermatol Surg. 1995 Sep;21(9):767-70.
The presence of infraobital dark skin, often known as dark circles under the eyes, is a frequent cosmetic concern. There has been little reported on therapy of this condition. One group of patients was determined to have dermal melanin deposition, which we treated with a Q-switched ruby laser.
Our study evaluated the clinical and histological appearance of infraobital skin pigment in 17 patients with dermal melanin deposition treated with a Q-switched ruby laser.
Seventeen patients with melanin deposition were treated with the Q-switched ruby laser (694 nm) with a pulse width of 28 nanoseconds and fluences of 7.5 J/cm2. Response to treatment was assessed by an independent investigator with patient and photograph evaluation. Skin Biopsies were obtained in nine of the 17 patients.
Of those patients treated with one Q-switched ruby session, 23.5% achieved a greater than 50% response. Of those treated twice, 88.9% achieved greater than 50% response. In postreatment skin biopsies there was reduction of dermal melanin deposition.
Patients with infraobital pigmented skin due to dermal melanin deposition may be considered candidates for Q-switched Ruby laser treatment.
眶下皮肤暗沉，通常被称为黑眼圈，是常见的美容问题。关于这种情况的治疗报道较少。一组患者被确定存在真皮黑色素沉积，我们用调Q红宝石激光对其进行治疗。
我们的研究评估了17例经调Q红宝石激光治疗的真皮黑色素沉积患者眶下皮肤色素的临床和组织学表现。
17例黑色素沉积患者接受调Q红宝石激光（694nm）治疗，脉冲宽度为28纳秒，能量密度为7.5J/cm²。由一名独立研究者通过患者和照片评估来评估治疗反应。17例患者中有9例进行了皮肤活检。
接受一次调Q红宝石激光治疗的患者中，23.5%的患者反应率超过50%。接受两次治疗的患者中，88.9%的患者反应率超过50%。治疗后皮肤活检显示真皮黑色素沉积减少。
因真皮黑色素沉积导致眶下皮肤色素沉着的患者可考虑作为调Q红宝石激光治疗的候选对象。
