Hiramatsu T, Imoto M, Koyano T, Umezawa K
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Cancer Lett. 1993 Sep 30;73(2-3):161-6. doi: 10.1016/0304-3835(93)90259-c.
We have screened tropical plant extracts for substances that induce normal morphology in K-rasts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure in K-rasts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. The effect of damnacanthal was reversible, and the compound had no effect on the morphology of RSVts-NRK cells expressing the src oncogene. Thus, damnacanthal is a new inhibitor of ras function.
我们筛选了热带植物提取物，以寻找能在K-rasts-NRK细胞中诱导正常形态的物质。结果，我们从巴戟天根部的氯仿提取物中分离出一种蒽醌化合物——虎刺醛。在允许温度下，虎刺醛能诱导K-rasts-NRK细胞呈现正常形态和细胞骨架结构，且不改变Ras的数量和定位。虎刺醛的作用是可逆的，该化合物对表达src癌基因的RSVts-NRK细胞的形态没有影响。因此，虎刺醛是一种新的Ras功能抑制剂。
