Hayasaka S, Fujii M, Yamamoto Y, Noda S, Kurome H, Sasaki M
Department of Ophthalmology, Shimane Medical University, Japan.
Br J Ophthalmol. 1995 Feb;79(2):150-2. doi: 10.1136/bjo.79.2.150.
A total of 43 patients (86 eyes) with chronic viral hepatitis were examined prospectively before and after the start of interferon therapy. Of 37 non-diabetic patients, 23 (group A1) did not have retinopathy or subconjunctival haemorrhage, 11 (group A2) developed retinopathy, and three (group A3) exhibited subconjunctival haemorrhage during the treatment. In most eyes, the retinopathy disappeared after therapy was stopped. Of six diabetic patients, three (group B1) developed retinopathy and three (group B2) showed progression of existing retinopathy. Thrombocytopenia was not associated with the retinopathy in any patient. The patients' good visual acuity remained unchanged, even after retinal changes appeared. Ophthalmologists should be aware that retinopathy and subconjunctival haemorrhage may develop in patients with chronic viral hepatitis receiving interferon therapy.
对43例（86只眼）慢性病毒性肝炎患者在干扰素治疗开始前后进行了前瞻性检查。在37例非糖尿病患者中，23例（A1组）未出现视网膜病变或结膜下出血，11例（A2组）出现视网膜病变，3例（A3组）在治疗期间出现结膜下出血。在大多数眼中，停止治疗后视网膜病变消失。在6例糖尿病患者中，3例（B1组）出现视网膜病变，3例（B2组）显示原有视网膜病变进展。血小板减少症在任何患者中均与视网膜病变无关。即使出现视网膜改变，患者的良好视力仍保持不变。眼科医生应意识到，接受干扰素治疗的慢性病毒性肝炎患者可能会出现视网膜病变和结膜下出血。
