Ganguly R, Cusumano C L, Waldman R H
Infect Immun. 1976 Feb;13(2):464-9. doi: 10.1128/iai.13.2.464-469.1976.
The effects of attenuated rubella virus infection upon cell-mediated immunity of human volunteers were studied. The volunteers received the vaccine either by nose drops or by the subcutaneous route. Changes in cell-mediated immunity in terms of delayed cutaneous sensitivity to recall antigens, phytohemagglutination stimulation, and spontaneous migration inhibitory factor-like activity were studied at various time periods after infection. Spontaneous migration inhibitory factor-like activity was studied on supernatants of the lymphocytes obtained from the volunteers and incubated for 72 h in the absence of any antigens. A significant proportion of the volunteers showed suppression of one or more parameters of cell-medicated immunity tested by week 2 of infection compared to the control; however, there was no correlation between suppression of the various parameters studied. No difference was noticed in the incidence of cell-mediated immunity suppression between nose drops and subcutaneous route groups.
研究了减毒风疹病毒感染对人类志愿者细胞介导免疫的影响。志愿者通过滴鼻或皮下途径接种疫苗。在感染后的不同时间段，研究了细胞介导免疫在对回忆抗原的迟发型皮肤敏感性、植物血凝素刺激以及自发迁移抑制因子样活性方面的变化。自发迁移抑制因子样活性是在从志愿者获得的淋巴细胞上清液中进行研究的，这些淋巴细胞在无任何抗原的情况下孵育72小时。与对照组相比，相当比例的志愿者在感染后第2周时，其一项或多项细胞介导免疫参数受到抑制；然而，所研究的各项参数的抑制之间并无相关性。滴鼻组和皮下途径组在细胞介导免疫抑制的发生率上未发现差异。
