淋病奈瑟菌喹诺酮耐药临床分离株中的DNA回旋酶突变
DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.
作者信息
Deguchi T, Yasuda M, Asano M, Tada K, Iwata H, Komeda H, Ezaki T, Saito I, Kawada Y
机构信息
Department of Urology, Gifu University, Japan.
出版信息
Antimicrob Agents Chemother. 1995 Feb;39(2):561-3. doi: 10.1128/AAC.39.2.561.
Abstract
Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.
摘要
8株耐喹诺酮淋病奈瑟菌临床分离株的GyrA蛋白显示存在突变。6株分离株在与大肠杆菌Ser-83相对应的位置有一个丝氨酸到苯丙氨酸的单氨基酸变化。除了丝氨酸到苯丙氨酸的变化外，2株分离株在与大肠杆菌Asp-87相对应的位置还有另一个天冬氨酸到天冬酰胺的变化。
相似文献
1
DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.淋病奈瑟菌喹诺酮耐药临床分离株中的DNA回旋酶突变
Antimicrob Agents Chemother. 1995 Feb;39(2):561-3. doi: 10.1128/AAC.39.2.561.
2
Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.耐喹诺酮淋病奈瑟菌：DNA 回旋酶 GyrA 亚基和拓扑异构酶 IV 的 ParC 亚基改变与抗菌药物敏感性谱的相关性
Antimicrob Agents Chemother. 1996 Apr;40(4):1020-3. doi: 10.1128/AAC.40.4.1020.
3
Mutation in DNA gyrase of norfloxacin-resistant clinical isolates of Neisseria gonorrhoeae.淋病奈瑟菌耐诺氟沙星临床分离株的DNA促旋酶突变
Genitourin Med. 1996 Aug;72(4):295-7. doi: 10.1136/sti.72.4.295.
4
Susceptibilities of Neisseria gonorrhoeae isolates containing amino acid substitutions in GyrA, with or without substitutions in ParC, to newer fluoroquinolones and other antibiotics.在GyrA中含有氨基酸替代、无论是否在ParC中也有替代的淋病奈瑟菌分离株对新型氟喹诺酮类药物和其他抗生素的敏感性。
Antimicrob Agents Chemother. 2000 Jan;44(1):192-5. doi: 10.1128/AAC.44.1.192-195.2000.
5
In vitro selection of fluoroquinolone-resistant Neisseria gonorrhoeae harboring alterations in DNA gyrase and topoisomerase IV.体外筛选携带DNA促旋酶和拓扑异构酶IV改变的耐氟喹诺酮淋病奈瑟菌。
J Urol. 2000 Sep;164(3 Pt 1):847-51. doi: 10.1097/00005392-200009010-00060.
6
Detection of mutations in the gyrA and parC genes in quinolone-resistant clinical isolates of Enterobacter cloacae.阴沟肠杆菌喹诺酮耐药临床分离株中gyrA和parC基因突变的检测
J Antimicrob Chemother. 1997 Oct;40(4):543-9. doi: 10.1093/jac/40.4.543.
7
Serotyping of quinolone-resistant Neisseria gonorrhoeae isolates with alterations in GyrA and ParC.对具有GyrA和ParC改变的耐喹诺酮淋病奈瑟菌分离株进行血清分型。
J Antimicrob Chemother. 1998 Mar;41(3):418-20. doi: 10.1093/jac/41.3.418.
8
Reduced clinical efficacy of pazufloxacin against gonorrhea due to high prevalence of quinolone-resistant isolates with the GyrA mutation. The Pazufloxacin STD Group.由于携带GyrA突变的喹诺酮耐药菌株普遍存在，帕珠沙星治疗淋病的临床疗效降低。帕珠沙星性传播疾病研究组。
Antimicrob Agents Chemother. 1998 Mar;42(3):579-82. doi: 10.1128/AAC.42.3.579.
9
Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Neisseria gonorrhoeae with genetic alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV.新型氟喹诺酮类药物DU-6859a对DNA旋转酶GyrA亚基和拓扑异构酶IV的ParC亚基发生基因改变的耐喹诺酮淋病奈瑟菌临床分离株的抗菌活性。
J Antimicrob Chemother. 1997 Feb;39(2):247-9. doi: 10.1093/jac/39.2.247.
10
Ciprofloxacin and the fluoroquinolones. New concepts on the mechanism of action and resistance.环丙沙星与氟喹诺酮类药物。作用机制与耐药性的新概念
Am J Med. 1989 Nov 30;87(5A):2S-8S. doi: 10.1016/0002-9343(89)90010-7.
引用本文的文献
1
A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch.Pathogenwatch 上的淋病奈瑟菌基因组流行病学和抗微生物药物耐药性预测的社区驱动资源。
Genome Med. 2021 Apr 19;13(1):61. doi: 10.1186/s13073-021-00858-2.
2
and Activities of TP0480066, a Novel Topoisomerase Inhibitor, against Neisseria gonorrhoeae.新型拓扑异构酶抑制剂 TP0480066 对淋病奈瑟菌的作用。
Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.02145-20.
3
In Vitro Activity of Delafloxacin against Clinical Neisseria gonorrhoeae Isolates and Selection of Gonococcal Delafloxacin Resistance.达氟沙星对临床淋病奈瑟菌分离株的体外活性及淋病奈瑟菌对达氟沙星耐药性的选择
Antimicrob Agents Chemother. 2016 Apr 22;60(5):3106-11. doi: 10.1128/AAC.02798-15. Print 2016 May.
4
Molecular characterization of quinolone-resistant Neisseria gonorrhoeae isolates from Brazil.巴西淋病奈瑟菌分离株中喹诺酮类耐药的分子特征。
J Clin Microbiol. 2011 Dec;49(12):4208-12. doi: 10.1128/JCM.01175-11. Epub 2011 Oct 5.
5
Cephalosporin Resistance in Neisseria gonorrhoeae.淋病奈瑟菌中的头孢菌素耐药性
J Glob Infect Dis. 2010 Sep;2(3):284-90. doi: 10.4103/0974-777X.68537.
6
Fluoroquinolone resistance and mutation patterns in gyrA and parC genes in Neisseria gonorrhoeae isolates from Shanghai, China.中国上海淋病奈瑟菌分离株中氟喹诺酮耐药性及gyrA和parC基因的突变模式
J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29(1):29-34. doi: 10.1007/s11596-009-0106-4. Epub 2009 Feb 18.
7
Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains.临床淋病奈瑟菌菌株耐药性的基因标志物与药敏谱之间的关系。
Antimicrob Agents Chemother. 2008 Jun;52(6):2175-82. doi: 10.1128/AAC.01420-07. Epub 2008 Mar 31.
8
Molecular characterization of Neisseria gonorrhoeae identifies transmission and resistance of one ciprofloxacin-resistant strain.淋病奈瑟菌的分子特征鉴定了一株耐环丙沙星菌株的传播和耐药性。
APMIS. 2007 Mar;115(3):231-41. doi: 10.1111/j.1600-0463.2007.apm_487.x.
9
Detection of gyrA mutations associated with ciprofloxacin resistance in Neisseria gonorrhoeae by rapid and reliable pre-programmed short DNA sequencing.通过快速可靠的预编程短DNA测序检测淋病奈瑟菌中与环丙沙星耐药相关的gyrA突变。
Int J Antimicrob Agents. 2005 Dec;26(6):486-90. doi: 10.1016/j.ijantimicag.2005.08.017. Epub 2005 Nov 7.
10
In vitro assessment of the further potential for development of fluoroquinolone resistance in Neisseria meningitidis.脑膜炎奈瑟菌对氟喹诺酮耐药性进一步发展潜力的体外评估
Antimicrob Agents Chemother. 2005 May;49(5):1753-60. doi: 10.1128/AAC.49.5.1753-1760.2005.
本文引用的文献
1
Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coli.一株高度耐氟喹诺酮的大肠杆菌临床分离株gyrA基因中的突变。
Antimicrob Agents Chemother. 1993 Apr;37(4):696-701. doi: 10.1128/AAC.37.4.696.
2
Cloning and nucleotide sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations.空肠弯曲菌gyrA基因的克隆、核苷酸序列及喹诺酮耐药性突变的特征分析
Antimicrob Agents Chemother. 1993 Mar;37(3):457-63. doi: 10.1128/AAC.37.3.457.
3
A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex.DNA 回旋酶 A 蛋白中的单个点突变极大地降低了氟喹诺酮类药物与回旋酶-DNA 复合物的结合。
Antimicrob Agents Chemother. 1993 Jan;37(1):126-7. doi: 10.1128/AAC.37.1.126.
4
Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.结核分枝杆菌gyrA和gyrB基因的克隆、核苷酸序列测定及喹诺酮耐药性突变检测
Antimicrob Agents Chemother. 1994 Apr;38(4):773-80. doi: 10.1128/AAC.38.4.773.
5
Mapping the active site tyrosine of Escherichia coli DNA gyrase.绘制大肠杆菌DNA促旋酶的活性位点酪氨酸图谱。
J Biol Chem. 1987 Apr 15;262(11):5339-44.
6
Structure and function of the region of the replication origin of the Bacillus subtilis chromosome. III. Nucleotide sequence of some 10,000 base pairs in the origin region.枯草芽孢杆菌染色体复制起点区域的结构与功能。III. 起点区域约10,000个碱基对的核苷酸序列。
Nucleic Acids Res. 1985 Apr 11;13(7):2251-65. doi: 10.1093/nar/13.7.2251.
7
Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase.编码DNA促旋酶A亚基的大肠杆菌gyrA基因的克隆与测序。
J Mol Biol. 1987 Oct 20;197(4):729-36. doi: 10.1016/0022-2836(87)90479-7.
8
Cloning and characterization of a DNA gyrase A gene from Escherichia coli that confers clinical resistance to 4-quinolones.来自大肠杆菌的一种赋予对4-喹诺酮类临床耐药性的DNA促旋酶A基因的克隆与特性分析。
Antimicrob Agents Chemother. 1989 Jun;33(6):886-94. doi: 10.1128/AAC.33.6.886.
9
DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli.金黄色葡萄球菌环丙沙星耐药菌株中的DNA促旋酶gyrA突变：与大肠杆菌喹诺酮耐药突变极为相似。
J Bacteriol. 1990 Dec;172(12):7260-2. doi: 10.1128/jb.172.12.7260-7262.1990.
10
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.大肠杆菌DNA促旋酶gyrA基因中的喹诺酮耐药决定区。
Antimicrob Agents Chemother. 1990 Jun;34(6):1271-2. doi: 10.1128/AAC.34.6.1271.
Zotero 插件