淋病奈瑟菌喹诺酮耐药临床分离株中的DNA回旋酶突变
DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae.
作者信息
Deguchi T, Yasuda M, Asano M, Tada K, Iwata H, Komeda H, Ezaki T, Saito I, Kawada Y
机构信息
Department of Urology, Gifu University, Japan.
出版信息
Antimicrob Agents Chemother. 1995 Feb;39(2):561-3. doi: 10.1128/AAC.39.2.561.
Abstract
Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.
摘要
8株耐喹诺酮淋病奈瑟菌临床分离株的GyrA蛋白显示存在突变。6株分离株在与大肠杆菌Ser-83相对应的位置有一个丝氨酸到苯丙氨酸的单氨基酸变化。除了丝氨酸到苯丙氨酸的变化外，2株分离株在与大肠杆菌Asp-87相对应的位置还有另一个天冬氨酸到天冬酰胺的变化。
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