大肠杆菌dnaZ基因产物参与体外DNA延伸过程。
Involvement of escherichia coli dnaZ gene product in DNA elongation in vitro.
作者信息
Wickner S, Hurwitz J
出版信息
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1053-7. doi: 10.1073/pnas.73.4.1053.
Abstract
E. coli dnaZ gene product is required for conversion of phiX174, fd, and ST-1 single-stranded phage DNAs to duplex DNAs in vitro. This protein has been purified about 5000-fold. It functions in the elongation of RNA- or DNA-primed single-stranded DNA that is catalyzed by DNA polymerase III(DNA nucleotidyltransferase; deoxynucleosidetriphosphate: DNA deoxynucleotidyltransferase; EC 2.7.7.7) in conjunctions with two other E. coli protein preparations referred to as DNA elongation factors I and III. It also functions in similar reactions catalyzed by DNA polymerase II in combination with E. coli DNA binding protein and DNA elongation factors I and III.
摘要
大肠杆菌dnaZ基因产物是体外将φX174、fd和ST - 1单链噬菌体DNA转化为双链DNA所必需的。这种蛋白质已被纯化了约5000倍。它在由DNA聚合酶III（DNA核苷酸转移酶；脱氧核苷三磷酸：DNA脱氧核苷酸转移酶；EC 2.7.7.7）催化的RNA或DNA引发的单链DNA延伸过程中发挥作用，与另外两种被称为DNA延伸因子I和III的大肠杆菌蛋白质制剂协同作用。它也在由DNA聚合酶II与大肠杆菌DNA结合蛋白以及DNA延伸因子I和III共同催化的类似反应中发挥作用。
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本文引用的文献
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