Le Huec J C, Schaeverbeke T, Clement D, Faber J, Le Rebeller A
Service d'Orthopédie, Chu Bordeaux, France.
Biomaterials. 1995 Jan;16(2):113-8. doi: 10.1016/0142-9612(95)98272-g.
Calcium phosphate ceramics are biocompatible and may develop interactions with human living bone tissues. They are used clinically on the surface of orthopaedic implants to improve primary fixation or in the form of porous blocks. Their brittleness is often advanced as a limitation of their common clinical use. In order to study the influence of porosity on the mechanical strength of calcium phosphate ceramics, we have tested 150 cylindrical hydroxyapatite samples with open porosity. The total porous volume of the ceramics has been varied from 20% to 60% and the pore size from 5 microns to 400 microns. The result indicates that not only total porosity but also pore size can influence compressive strength, which is in good agreement with theoretical work. After mathematical treatment of the results, the experiments have been modelled in the form of a polynomial equation which can be used to predict and optimize mechanical strength. Moreover, this work supports the fact that compressive strength of controlled open porosity implants can be comparable with that of cancellous or cortical human bone, and suggests that porosity should be fitted to clinical application.
磷酸钙陶瓷具有生物相容性，可能与人体活骨组织发生相互作用。它们在临床上用于骨科植入物表面以改善初始固定，或制成多孔块状使用。其脆性常被视为限制其临床广泛应用的因素。为了研究孔隙率对磷酸钙陶瓷机械强度的影响，我们测试了150个具有开孔孔隙率的圆柱形羟基磷灰石样品。陶瓷的总孔隙体积从20%变化到60%，孔径从5微米到400微米。结果表明，不仅总孔隙率，而且孔径都会影响抗压强度，这与理论研究结果高度一致。对结果进行数学处理后，实验被建模为一个多项式方程，该方程可用于预测和优化机械强度。此外，这项研究支持了以下事实：具有可控开孔孔隙率的植入物的抗压强度可与人体松质骨或皮质骨相媲美，并表明孔隙率应根据临床应用进行调整。
