Weiser R S, Erickson D, Perine P L, Pearsall N N
Infect Immun. 1976 May;13(5):1402-7. doi: 10.1128/iai.13.5.1402-1407.1976.
The influence of prolonged treatment with serial doses of immune serum initiated either 2 or 48 h before intracutaneous challenge with Treponema pallidum on the subsequent appearance and development of lesions was studied. Whereas treatment with large doses of immune serum initiated 48 h before treponemal challenge caused a delay of 9 to 20 days in the onset of lesions and marked suppression of lesion development. Treatment initiated 2 h before treponemal challenge failed to delay the onset of lesions and only moderately suppressed their development. Lesion development was suppressed as long as treatment was continued. The significance of the results is discussed.
研究了在皮内接种梅毒螺旋体前2小时或48小时开始连续给予免疫血清进行长期治疗，对随后病变的出现和发展的影响。在梅毒螺旋体攻击前48小时开始用大剂量免疫血清治疗，会使病变出现延迟9至20天，并显著抑制病变发展。在梅毒螺旋体攻击前2小时开始治疗未能延迟病变出现，仅适度抑制其发展。只要持续治疗，病变发展就会受到抑制。讨论了结果的意义。
