梅毒免疫：使用系列剂量免疫血清在兔体内进行被动转移
Immunity to syphilis: passive transfer in rabbits using serial doses of immune serum.
作者信息
Weiser R S, Erickson D, Perine P L, Pearsall N N
出版信息
Infect Immun. 1976 May;13(5):1402-7. doi: 10.1128/iai.13.5.1402-1407.1976.
Abstract
The influence of prolonged treatment with serial doses of immune serum initiated either 2 or 48 h before intracutaneous challenge with Treponema pallidum on the subsequent appearance and development of lesions was studied. Whereas treatment with large doses of immune serum initiated 48 h before treponemal challenge caused a delay of 9 to 20 days in the onset of lesions and marked suppression of lesion development. Treatment initiated 2 h before treponemal challenge failed to delay the onset of lesions and only moderately suppressed their development. Lesion development was suppressed as long as treatment was continued. The significance of the results is discussed.
摘要
研究了在皮内接种梅毒螺旋体前2小时或48小时开始连续给予免疫血清进行长期治疗，对随后病变的出现和发展的影响。在梅毒螺旋体攻击前48小时开始用大剂量免疫血清治疗，会使病变出现延迟9至20天，并显著抑制病变发展。在梅毒螺旋体攻击前2小时开始治疗未能延迟病变出现，仅适度抑制其发展。只要持续治疗，病变发展就会受到抑制。讨论了结果的意义。
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本文引用的文献
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Study of the antigenic structure of Treponema pallidum by specific agglutination.通过特异性凝集研究梅毒螺旋体的抗原结构。
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Treponema pallidum within cells of a primary chancre from a human female.来自一名人类女性一期梅毒硬下疳细胞内的梅毒螺旋体。
Br J Vener Dis. 1974 Feb;50(1):40-4. doi: 10.1136/sti.50.1.40.
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Effects of passive immunization on experimental syphilis in the rabbit.被动免疫对兔实验性梅毒的影响。
Johns Hopkins Med J. 1973 Nov;133(5):241-51.
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Immunity to syphilis. I. Passive transfer in rabbits with hyperimmune serum.梅毒免疫。一、用超免疫血清在兔体内进行被动转移
Infect Immun. 1973 Nov;8(5):787-90. doi: 10.1128/iai.8.5.787-790.1973.
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Attempt to protect rabbits against experimental syphilis by passive immunization.尝试通过被动免疫保护兔子免受实验性梅毒感染。
Br J Vener Dis. 1973 Aug;49(4):335-7. doi: 10.1136/sti.49.4.335.
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Lymphokine toxicity for yeast cells.淋巴细胞因子对酵母细胞的毒性。
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Reduced lymphocyte transformation due to a plasma factor in patients with active syphilis.活动性梅毒患者血浆因子导致淋巴细胞转化降低。
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