Isolauri J, Laippala P
Department of Clinical Medicine, University of Tampere, Finland.
Ann Med. 1995 Feb;27(1):67-70. doi: 10.3109/07853899509031939.
Symptoms suggestive of gastro-oesophageal reflux disease are very common. The aim of the study was to assess the prevalence of these symptoms and factors influencing them in an unselected adult population. A questionnaire was mailed to a random sample of 2500 people aged > or = 20 years. The questions concerned heartburn, regurgitation, dysphagia, chest and upper abdominal pain, as well as medication and medical consultations for these symptoms. Of the 1700 (68%) responders, 9% had experienced heartburn on the day of response and 15%, 21% and 27% during the preceding week, month and year, respectively. The corresponding figures for regurgitation were 5, 15, 29 and 45%. During the past year 43% of the study group had had no such symptoms. Age, overweight, pregnancy and cigarette smoking significantly influenced the prevalence of symptoms. Using daily heartburn and/or regurgitation as dominant indicators 10.3% (95% CI 12-11.7) of the responders had gastro-oesophageal reflux disease. Medication (most commonly antacids) was used by only 16% of the symptomatic people, and only 5.5% had sought medical advice for symptoms during the past year. Thus, despite commonness of symptoms suggestive of gastro-oesophageal reflux disease only a minority of the individuals suffering from such symptoms use medication or have medical consultation.
提示胃食管反流病的症状非常常见。本研究的目的是评估这些症状在未经过筛选的成年人群中的患病率及其影响因素。一份问卷被邮寄给了2500名年龄大于或等于20岁的随机抽样人群。问题涉及烧心、反流、吞咽困难、胸部和上腹部疼痛,以及针对这些症状的用药和就医情况。在1700名(68%)回复者中,9%在回复当天有过烧心症状,在前一周、一个月和一年中出现烧心症状的比例分别为15%、21%和27%。反流症状的相应比例分别为5%、15%、29%和45%。在过去一年中,43%的研究组人群没有出现过此类症状。年龄、超重、怀孕和吸烟显著影响症状的患病率。以每日烧心和/或反流作为主要指标,10.3%(95%置信区间12 - 11.7)的回复者患有胃食管反流病。只有16%的有症状者使用过药物(最常见的是抗酸剂),并且在过去一年中只有5.5%的人因症状寻求过医疗建议。因此,尽管提示胃食管反流病的症状很常见,但只有少数有此类症状的人使用药物或寻求医疗咨询。