McElhaney J E, Meneilly G S, Pinkoski M J, Lechelt K E, Bleackley R C
Department of Medicine, University of Alberta, Edmonton, Canada.
Vaccine. 1995 Jan;13(1):6-10. doi: 10.1016/0264-410x(95)80003-v.
This study was designed as a parallel-groups comparison of trivalent preparations of split-virus vaccine (SVV) and whole-virus influenza vaccine (WVV) in healthy young and elderly adults. Interleukin-2 (IL-2) was measured in the supernatants of peripheral blood mononuclear cell (PBMC) cultures stimulated with live virus preparations of the two strains of influenza A contained in the vaccine. The duration of increased in vitro IL-2 production after vaccination was significantly different between the two strains of virus. A/Beijing/353/89 resulted in an IL-2 response that was quite short (< 7 weeks) while the response to A/Texas/16/89 was much more prolonged (> 12 weeks). In the first 12 weeks after vaccination, there was no difference in IL-2 levels between SVV and WVV recipients in either the young or elderly groups. The duration of the response to A/Texas/16/89 was slightly longer in WVV recipients as measured at 26 weeks postvaccination. The viral strain contained in the vaccine appears to be an important variable in determining the duration of the IL-2 response to vaccination.
本研究旨在对健康的年轻人和老年人中三价裂解病毒疫苗（SVV）和全病毒流感疫苗（WVV）制剂进行平行组比较。在用疫苗中所含两种甲型流感病毒株的活病毒制剂刺激外周血单核细胞（PBMC）培养上清液中测量白细胞介素-2（IL-2）。接种疫苗后体外IL-2产生增加的持续时间在两种病毒株之间存在显著差异。A/北京/353/89导致的IL-2反应相当短暂（<7周），而对A/德克萨斯/16/89的反应则更为持久（>12周）。在接种疫苗后的前12周，年轻组和老年组中SVV和WVV接种者的IL-2水平没有差异。在接种疫苗后26周测量时，WVV接种者对A/德克萨斯/16/89的反应持续时间略长。疫苗中所含的病毒株似乎是决定接种疫苗后IL-2反应持续时间的一个重要变量。
