Port E, Sun F, Martin D, Waterman M S
Department of Mathematics, University of Southern California, Los Angeles 90089-1113, USA.
Genomics. 1995 Mar 1;26(1):84-100. doi: 10.1016/0888-7543(95)80086-2.
Physical maps can be constructed by "fingerprinting" a large number of random clones and inferring overlap between clones when the fingerprints are sufficiently similar. E. Lander and M. Waterman (Genomics 2: 231-239, 1988) gave a mathematical analysis of such mapping strategies. The analysis is useful for comparing various fingerprinting methods. Recently it has been proposed that ends of clones rather than the entire clone be fingerprinted or characterized. Such fingerprints, which include sequenced clone ends, require a mathematical analysis deeper than that of Lander-Waterman. This paper studies clone islands, which can include uncharacterized regions, and also the islands that are formed entirely from the ends of clones.
物理图谱可以通过对大量随机克隆进行“指纹识别”，并在指纹足够相似时推断克隆之间的重叠来构建。E. 兰德和M. 沃特曼（《基因组学》2: 231 - 239, 1988）对这种图谱构建策略进行了数学分析。该分析对于比较各种指纹识别方法很有用。最近有人提出对克隆的末端而不是整个克隆进行指纹识别或特征描述。这种指纹，包括已测序的克隆末端，需要比兰德 - 沃特曼分析更深层次的数学分析。本文研究了克隆岛，其可以包括未特征化的区域，以及完全由克隆末端形成的岛。
