单向转运体/同向转运体/反向转运体超家族的结构特征。
Structural features of the uniporter/symporter/antiporter superfamily.
作者信息
Goswitz V C, Brooker R J
机构信息
Department of Genetics and Cell Biology, University of Minnesota, St. Paul 55108, USA.
出版信息
Protein Sci. 1995 Mar;4(3):534-7. doi: 10.1002/pro.5560040319.
Abstract
The uniporter/symporter/antiporter superfamily is an evolutionarily related group of solute transporters. For the entire superfamily, we have used a new predictive program to identify the transmembrane domains. These transmembrane domains were then analyzed with regard to their overall hydrophobicity and amphipathicity. In addition, the lengths of the hydrophilic loops connecting the transmembrane domains were calculated. These data, together with structural information in the literature, were collectively used to produce a general model for the three-dimensional arrangement of the transmembrane domains.
摘要
单向转运体/同向转运体/反向转运体超家族是一组在进化上相关的溶质转运蛋白。对于整个超家族，我们使用了一个新的预测程序来识别跨膜结构域。然后分析这些跨膜结构域的整体疏水性和两亲性。此外，还计算了连接跨膜结构域的亲水环的长度。这些数据，连同文献中的结构信息，共同用于生成跨膜结构域三维排列的通用模型。
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