Charpentier E, Gerbaud G, Jacquet C, Rocourt J, Courvalin P
Unité des Agents Antibactériens, Institut Pasteur, Paris, France.
J Infect Dis. 1995 Jul;172(1):277-81. doi: 10.1093/infdis/172.1.277.
To define the prevalence of antibiotic resistance in Listeria species pathogenic for humans and animals, 1100 isolates (60 from cases of listeriosis and 1040 from food and environment) collected worldwide were screened. Of the 61 tetracycline- and minocycline-resistant strains (37 Listeria monocytogenes), 57 harbored tet(M); 4 non-L. monocytogenes isolates contained tet(S). One Listeria innocua isolate was also resistant to streptomycin and contained the tet(M) and aad6 genes. An L. monocytogenes isolate was trimethoprim-resistant, a characteristic not reported previously in Listeria species, because of the presence of a yet-uncharacterized gene. Three clinical isolates of L. monocytogenes were resistant to low levels of streptomycin. Since the tet(M), tet(S), and aad6 genes are common in enterococci and streptococci, these data suggest transfer from the latter to Listeria species. Uniform susceptibility to tetracycline, minocycline, trimethoprim, and streptomycin cannot be assumed any longer for Listeria species.
为确定对人和动物致病的李斯特菌属中抗生素耐药性的流行情况，对全球收集的1100株分离株（60株来自李斯特菌病病例，1040株来自食品和环境）进行了筛查。在61株对四环素和米诺环素耐药的菌株（37株单核细胞增生李斯特菌）中，57株携带tet(M)；4株非单核细胞增生李斯特菌分离株含有tet(S)。1株无害李斯特菌分离株也对链霉素耐药，并含有tet(M)和aad6基因。1株单核细胞增生李斯特菌分离株对甲氧苄啶耐药，这是李斯特菌属中以前未报道过的特征，原因是存在一个尚未鉴定的基因。3株单核细胞增生李斯特菌临床分离株对低水平链霉素耐药。由于tet(M)、tet(S)和aad6基因在肠球菌和链球菌中很常见，则这些数据表明这些基因是从后者转移至李斯特菌属。不能再认为李斯特菌属对四环素、米诺环素、甲氧苄啶和链霉素具有一致的敏感性。
